Dose-rate effects in normal and malignant cells of human origin
Autor: | Marco Zaider, Eric J. Hall, Michael J. Marchese |
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Rok vydání: | 1987 |
Předmět: |
medicine.medical_specialty
Cell Survival Normal tissue Dose-Response Relationship Radiation Neoplasms Experimental General Medicine In Vitro Techniques Human cell Biology Cell Line Surgery Andrology Survival data Cell culture medicine Humans Malignant cells Radiology Nuclear Medicine and imaging Continuous irradiation Dose rate Survival analysis |
Zdroj: | The British Journal of Radiology. 60:573-576 |
ISSN: | 1748-880X 0007-1285 |
DOI: | 10.1259/0007-1285-60-714-573 |
Popis: | Human cell lines derived from normal tissue and malignant tumours were irradiated in plateau phase under acute (81 Gy/h) or protracted (0.1-0.7 Gy/h) exposure to determine initial survival curve slopes, assess sublethal damage repair (SLDR) capability, and establish differences in survival due to SLDR over a range of dose rates. No correlation was found between clinical resistance of the tumor types and initial slope or survival at 2 Gy. Sublethal damage repair was assessed by comparing survival curves for acute and continuous irradiation. All cell lines showed significant SLDR, with the more clinically resistant tumour types demonstrating the best recovery rates. The survival data also demonstrated little difference in cell killing over the 0.1-0.7 Gy/h range. Using a modified linear-quadratic model with provisions for SLDR, it was found that for these cell lines the repair half-time was less than 1 h, with no significant change in the amount of recovery from sublethal damage at dose rates below 1 Gy/h. |
Databáze: | OpenAIRE |
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