Supplementary Figures from First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

Autor:	Howard A. Burris, Jared A. Gollob, Dinah W.Y. Sah, Akshay K. Vaishnaw, Christina Gamba-Vitalo, Saraswathy V. Nochur, Jeffrey Cehelsky, Valerie A. Clausen, Renta M. Hutabarat, Nenad Svrzikapa, Gregory Hinkle, Rachel E. Meyers, David Bumcrot, Iva Toudjarska, Amy C. Seila White, Jamie Harrop, Rick Falzone, Mrinal M. Gounder, Maria Alsina, Jeffrey R. Infante, Daniel C. Cho, Luis Paz-Ares, Glen J. Weiss, Gary K. Schwartz, Andres Cervantes, Patricia M. LoRusso, Geoffrey I. Shapiro, Josep Tabernero
Rok vydání:	2023
Popis:	Supplementary Figures PDF file - 114K, Includes sequence information on KSP and VEGF siRNAs, murine Hep3B tumor model data with ALN-VSP, ALN-VSP Phase I study design, KSP and VEGF mRNA levels in tumor cell lines and normal liver, and comparison of ALN-VSP PK data in cancer patients and non-human primates
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798921fa41c39c58506772199a018c15 https://doi.org/10.1158/2159-8290.22530521 Zobrazit plný text záznamu