Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-gamma
| Autor: | H M Shapiro, Vicki E. Kelley, Kenneth H. Mayer, W Heagy, Terry B. Strom, Robert W. Finberg, R Mandel |
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| Rok vydání: | 1984 |
| Předmět: |
Male
In Vitro Techniques Biology Monocytes Immune deficiency syndrome Flow cytometry Interferon-gamma Antigen medicine Humans Interferon gamma Lymphatic Diseases HLA-DR Antigen HLA-D Antigens Acquired Immunodeficiency Syndrome medicine.diagnostic_test Histocompatibility Antigens Class II HLA-DR Antigens Homosexuality General Medicine Flow Cytometry medicine.disease Lymphatic disease Histocompatibility Immunology Research Article medicine.drug |
| Zdroj: | Journal of Clinical Investigation. 74:2089-2096 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci111633 |
| Popis: | The expression of HLA-DR (a class II histocompatibility antigen) on monocytes isolated from the peripheral blood of normal individuals and patients with acquired immune deficiency syndrome (AIDS) was investigated by the use of dual fluorescent staining and cytofluorometry. In animal models the absence of class II positive monocytes is linked to a failure of T cells to respond to antigens. We now report that patients with AIDS have a paucity of HLA-DR+ monocytes. The percentage of HLA-DR+ monocytes among eight normal individuals ranged from 49.3 to 95.0%+, and only one individual had less than 50% HLA-DR+ monocytes. HLA-DR expression on monocytes from homosexual male patients with lymphadenopathy was similar to that of normal subjects (range, 58.0 to 97.4%+). In contrast, seven of nine patients with AIDS had less than 50% HLA-DR+ monocytes (range, 13.4 to 78.8%+). The in vitro incubation of monocytes from AIDS patients with cloned human interferon-gamma resulted in an increase of the expression of HLA-DR to near normal levels. |
| Databáze: | OpenAIRE |
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