Phase II trial of combination chemotherapy with fluorouracil (F), doxorubicin (A), and cisplatin (P) (Fap) in hormonally resistant metastatic prostatic adenocarcinoma
| Autor: | Gilles Piot, H. Lupera, Fargeot P, P Lapleige, Christine Theodore, Jean-Pierre Droz |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Gastroenterology Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Doxorubicin Neoplasm Metastasis Metastatic Prostatic Adenocarcinoma Aged Cisplatin Chemotherapy business.industry Prostatic Neoplasms Combination chemotherapy General Medicine Middle Aged medicine.disease Fluorouracil Drug Evaluation business medicine.drug |
| Zdroj: | Oncology. 46(6) |
| ISSN: | 0030-2414 |
| Popis: | From October 1985 to December 1986, 25 patients with advanced prostatic carcinoma were entered in a phase II trial and were administered fluorouracil (F) 600 mg/m2, on days 1 and 2, doxorubicin (A) 40 mg/m2, on day 1, and cisplatin (P) 90 mg/m2, on day 1, every month. The response was evaluated after three cycles of chemotherapy according to National Prostatic Cancer Project criteria. There were no complete remission, 1 partial remission, 13 stabilizations, 11 progressions. Toxicity was assessed using WHO criteria. Alopecia and vomiting were universal; there were 11 grade 1 anemias, 2 aplasias, and 1 grade 1 renal toxicity. A FAP regimen appears to exert a marginal effect in advanced prostatic carcinoma. |
| Databáze: | OpenAIRE |
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