THE BINDING OF TRIETHYLTIN TO RAT BRAIN MYELIN
| Autor: | W. N. Aldridge, E. A. Lock |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Receptors
Drug Affinity binding Binding Competitive Biochemistry Cellular and Molecular Neuroscience Myelin Competitive binding medicine Animals Binding site Myelin Sheath Binding Sites Trimethyltin Compounds Chemistry Brain Rat brain Rats Kinetics Lower affinity medicine.anatomical_structure Hexachlorophane Trialkyltin Compounds Triethyltin Compounds Mathematics Protein Binding |
| Zdroj: | Journal of Neurochemistry. 25:871-876 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.1975.tb04420.x |
| Popis: | —A high affinity binding site for triethyltin was found in rat brain myelin with an affinity of approx 6·6 × 105m−1 at pH 7·5. Competitive binding studies showed that triethyl-lcad had about the same affinity and trimethyltin 30 times lower affinity than triethyltin. Hexachlorophane and 3,5-diiodo-4′-chlorosalicylanilide did not prevent triethyltin binding to rat brain myelin. Since triethyltin, hexachlorophane and 3,5-diiodo-4′-chlorosalicylanilide all produce similar oedematous lesions in the brain of rats, whereas triethyl-lead and trimethyltin do not, it is concluded that the high affinity triethyltin binding site either is not involved or is not the only factor in oedema production. |
| Databáze: | OpenAIRE |
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