Zinc deficiency and zinc repletion: effect on the response of rats to infection with Trichinella spiralis
| Autor: | C Huber, P J Aggett, D Wakelin, D C Macdonald, P K Fenwick |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
T spiralis
medicine.medical_specialty Trichinella Trichinella spiralis Medicine (miscellaneous) chemistry.chemical_element Zinc Thymus Gland Weight loss Internal medicine medicine Animals Intestinal Diseases Parasitic Lost Weight Immunity Cellular Nutrition and Dietetics biology Body Weight Nutritional status Rats Inbred Strains Trichinellosis biology.organism_classification medicine.disease Diet Rats Intestines Endocrinology chemistry Immunology Zinc deficiency Female medicine.symptom Weight gain Spleen |
| Zdroj: | The American journal of clinical nutrition. 52(1) |
| ISSN: | 0002-9165 |
| Popis: | The expulsion of a primary infection of Trichinella spiralis was studied in rats fed diets containing (per kg diet) either 3 mg Zn [zinc deficient (Zn-)] or 40 mg Zn [zinc adequate (Zn+)]. A dose of 2000 muscle larvae (ML) impaired weight gain (mg/g body wt) in all groups compared with uninfected controls [eg, 0-7 d postinfection (dpi): infected Zn-, -105 +/- 10 (means +/- SEM); uninfected Zn-, 54 +/- 19 (p less than 0.001)]. In a study with 20.5 ML/g body wt, some Zn- rats were transferred at the time of infection to the zinc-adequate diet. [This was the zinc-repleted group (ZnR).] Both groups retained a group of pair-fed controls (Zn-PF and ZnRPF). The percentage dose established at 7 dpi was similar in all groups (32.5-39.3%) but at 13 dpi recoveries were 19.4 +/- 2.2% for Zn-, 0.1 +/- 0.1% for Zn-PF, 1.6 +/- 0.9% for ZnR, 0.6 +/- 0.2% for ZnRPF, and 4.1 +/- 2.2% for Zn+ (p less than 0.001). Up to 13 dpi, all groups except ZnR lost weight. These results show that zinc deficiency impairs the expulsion of T spiralis in rats. |
| Databáze: | OpenAIRE |
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