Effects of micellar oleic acid on canine jejunal blood flow and neurotensin release
| Autor: | E. D. Jacobson, R. H. Gallavan, K. D. Buchanan, C. Shaw, S. N. Joffe, Richard F. Murphy |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment Lumen (anatomy) Oleic Acids Biology digestive system Veins chemistry.chemical_compound Dogs Physiology (medical) Internal medicine medicine Animals Bile Colloids Saline Micelles Neurotensin Total blood Hepatology Gastroenterology Arteries Blood flow Oleic acid Jejunum Endocrinology medicine.anatomical_structure chemistry Vascular resistance Female Vascular Resistance Blood Flow Velocity hormones hormone substitutes and hormone antagonists Oleic Acid Hormone |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 251:G649-G655 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.1986.251.5.g649 |
| Popis: | The purpose of this study was to evaluate the role of neurotensin in the local regulation of the lipid-induced jejunal hyperemia. Total blood flow and the arteriovenous hormone concentration difference were measured in isolated jejunal loops of anesthetized dogs with either saline, bile (10% in normal saline), oleic acid (40 mM in normal saline), or oleic acid and bile in the lumen. The bile-oleic acid mixture produced a sustained increase (+25 +/- 3%) in jejunal blood flow, whereas neurotensin release reached a maximum (1.14 +/- 0.34 pmol X min-1 X 100 g-1) 2 min after initiation of the response and then returned to control. Venous neurotensin concentrations also reached a maximum (51 +/- 17 pmol/l) at 2 min. There were no significant changes in either blood flow or neurotensin release in response to the other test solutions. Intra-arterial infusion of neurotensin did not significantly decrease jejunal vascular resistance (-12 +/- 3%) until venous concentrations of 478 +/- 101 pmol/l were attained. It seems unlikely, then, that neurotensin plays any role in the regulation of the lipid-induced jejunal hyperemia |
| Databáze: | OpenAIRE |
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