Genetic and environmental influences interact with age and sex in shaping the human methylome
| Autor: | Joyce Van Meurs, Marc Jan Bonder, Marleen Van Greevenbroek, Michel Nivard, Morris Swertz, René Pool, H. Eka D. Suchiman, Coen Stehouwer, Marijn Verkerk, Cornelia Van Duijn, Jenny Van Dongen, Pieternella Slagboom, Marian Beekman, Casper G Schalkwijk, Szymon Kiełbasa, Lude Franke, Rick Jansen, Gonneke Willemsen, Carla Van der Kallen, Patrick Deelen |
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| Přispěvatelé: | Interne Geneeskunde, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Biological Psychology, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Netherlands Twin Register (NTR) Adult Male Aging Adolescent Science Inheritance Patterns General Physics and Astronomy Single-nucleotide polymorphism Biology Genome Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences Sex Factors SDG 3 - Good Health and Well-being Genetic variation Twins Dizygotic Humans Gene–environment interaction Genetics Multidisciplinary Genome Human Smoking Age Factors General Chemistry Twins Monozygotic Heritability DNA Methylation Explained variation 030104 developmental biology Phenotype Child Preschool DNA methylation CpG Islands Female Gene-Environment Interaction |
| Zdroj: | Nature Communications Nature Communications, 7:11115. Nature Publishing Group Nature Communications, 7. Nature Publishing Group van Dongen, J, Nivard, M G, Willemsen, G, Hottenga, J-J, Helmer, Q, Dolan, C V, Ehli, E A, Davies, G E, van Iterson, M, Breeze, C E, Beck, S, Suchiman, H E, Jansen, R, van Meurs, J B, Heijmans, B T, Slagboom, P E & Boomsma, D I 2016, ' Genetic and environmental influences interact with age and sex in shaping the human methylome ', Nature Communications, vol. 7 . https://doi.org/10.1038/ncomms11115 Nature Communications, 7(11115):11115, 1-13. Nature Publishing Group Nature Communications, 7 van Dongen, J, Nivard, M G, Willemsen, G, Hottenga, J J, Helmer, Q, Dolan, C V, Ehli, E A, Davies, G E, van Iterson, M, Breeze, C E, Beck, S, Pool, R, Suchiman, H E D, Jansen, R, van Meurs, J B, Heijmans, B T, Slagboom, P E & Boomsma, D I 2016, ' Genetic and environmental influences interact with age and sex in shaping the human methylome ', Nature Communications, vol. 7, no. 11115, 11115, pp. 1-13 . https://doi.org/10.1038/ncomms11115 Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms11115 |
| Popis: | The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation. Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation. |
| Databáze: | OpenAIRE |
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