Expression of hepatocyte growth factor and c-Met in non-small-cell lung cancer and association with lymphangiogenesis
| Autor: | Yuping Sun, Tanghong Jia, Liyun Qiu, Wenli Lin, Nan Zhang, Fubo Xie, Wei Gao, Shuwen Yu |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty C-Met Lung Neoplasms Vascular Endothelial Growth Factor C Gene Expression Biology Biochemistry chemistry.chemical_compound Carcinoma Non-Small-Cell Lung Genetics medicine Lymphatic vessel Humans Lymphangiogenesis Lung cancer Molecular Biology Aged Neoplasm Staging Aged 80 and over Hepatocyte Growth Factor Cancer Middle Aged Proto-Oncogene Proteins c-met medicine.disease Vascular endothelial growth factor Lymphatic system medicine.anatomical_structure Oncology chemistry Molecular Medicine Hepatocyte growth factor Female medicine.drug |
| Zdroj: | Molecular medicine reports. 11(4) |
| ISSN: | 1791-3004 |
| Popis: | Previous experimental studies have demonstrated that hepatocyte growth factor (HGF) and its receptor c‑Met serve an important function in lymphangiogenesis, but their biological functions in malignant tumors have remained elusive. The present study aimed to investigate the expression patterns of HGF‑α and c‑Met and their association with vascular endothelial growth factor (VEGF)‑C, lymphatic vessel density and lymph node metastasis in non‑small‑cell lung cancer (NSCLC). In the present study, the lymphatic microvessel density (LMVD) and the expression levels of HGF‑α, its receptor c‑Met and VEGF‑C were determined in 113 human NSCLC tissues and 113 normal lung tissue samples, using immunohistochemical staining. As a result, it was determined that the expression levels of HGF‑α, c‑Met and VEGF‑C were significantly higher in NSCLC tissues than those in normal lung tissues (HGF‑α, 67.3 vs. 20.4%, P |
| Databáze: | OpenAIRE |
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