Classification of Psychoses Based on Immunological Features: A Machine Learning Study in a Large Cohort of First-Episode and Chronic Patients
| Autor: | Nunzio Turtulici, Stefano Torresani, Paolo Brambilla, Alessandro Pigoni, Giuseppe Delvecchio, Armando D'Agostino, Cinzia Perlini, Annamaria Finardi, Gualtiero I Colombo, Maria Gloria Rossetti, Roberto Furlan, Chiara Bonetto, Filippo Maria Villa, Marcella Bellani, Mirella Ruggeri, Francesca Bellini, Paolo Scocco, Matteo Balestrieri, Paolo Enrico, Massimo Gennarelli, Antonio Lasalvia, Luisella Bocchio-Chiavetto, Angela Veronese, Massimiliano Imbesi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Psychosis Machine learning computer.software_genre Cohort Studies 03 medical and health sciences transcriptomics 0302 clinical medicine immune biomarkers immunity machine learning personalized medicine psychosis Chronic Disease Female Humans Machine Learning Middle Aged Psychotic Disorders medicine Bipolar disorder First episode business.industry medicine.disease 030227 psychiatry Psychiatry and Mental health Schizophrenia Cohort Major depressive disorder Biomarker (medicine) Artificial intelligence business computer 030217 neurology & neurosurgery Cohort study Regular Articles |
| Zdroj: | Schizophr Bull |
| Popis: | For several years, the role of immune system in the pathophysiology of psychosis has been well-recognized, showing differences from the onset to chronic phases. Our study aims to implement a biomarker-based classification model suitable for the clinical management of psychotic patients. A machine learning algorithm was used to classify a cohort of 362 subjects, including 160 first-episode psychosis patients (FEP), 70 patients affected by chronic psychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder) with psychosis (CRO) and 132 health controls (HC), based on mRNA transcript levels of 56 immune genes. Models distinguished between FEP, CRO, and HC and between the subgroup of drug-free FEP and HC with a mean accuracy of 80.8% and 90.4%, respectively. Interestingly, by using the feature importance method, we identified some immune gene transcripts that contribute most to the classification accuracy, possibly giving new insights on the immunopathogenesis of psychosis. Therefore, our results suggest that our classification model has a high translational potential, which may pave the way for a personalized management of psychosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|