Intralesional Collagenase Clostridium histolyticum Causes Meaningful Improvement in Men with Peyronie's Disease: Results of a Multi-Institutional Analysis
| Autor: | Martin K. Gelbard, Matthew Ziegelmann, Landon Trost, Wayne Jg Hellstrom, Laith Alzweri, Amanda S. J. Chung, Ramón Virasoro, Ashley Tapscott, Hoang Minh Tue Nguyen |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Penile Induration Treatment outcome 030232 urology & nephrology Injections Intralesional 03 medical and health sciences 0302 clinical medicine Collagenase clostridium histolyticum Clostridium histolyticum medicine Humans Aged Retrospective Studies Aged 80 and over biology business.industry Middle Aged medicine.disease biology.organism_classification Microbial Collagenase Treatment Outcome Microbial collagenase Peyronie's disease business medicine.drug |
| Zdroj: | Journal of Urology. 201:777-782 |
| ISSN: | 1527-3792 0022-5347 |
| Popis: | In a multi-institutional setting we studied the efficacy and safety outcomes at multiple high volume centers where collagenase Clostridium histolyticum is used to treat Peyronie's disease.We collected retrospective data on consecutive patients with Peyronie's disease who underwent treatment with collagenase C. histolyticum between April 2014 and March 2018 at a total of 5 institutions. Included in the study were 918 patients. Main outcomes of interest included the change in curvature after receiving collagenase C. histolyticum therapy and the frequency of serious treatment related adverse events. The 2-tailed paired Student t-test was used to compare continuous variables. Univariate and multivariate regression analyses were performed to assess predictors of the success of collagenase C. histolyticum therapy to improve curvature.In the cohort of 918 patients curvature improved from a mean of 48.2 degrees before treatment to 32.9 degrees after treatment, a 30.1% improvement from baseline (p0.0001). Of the men 68.7% had a 20% or greater improvement in curvature. In the 502 patients who completed 4 or more cycles curvature improved from a mean of 49.7 degrees before to 32.7 degrees after treatment, a 33% improvement from baseline (p0.0001). Of these men 74.4% experienced a 20% or greater improvement in curvature. A complication of treatment developed in 9% of patients. The number of cycles of collagenase C. histolyticum received was predictive of curvature improvement (p0.0001).This large multi-institutional analysis confirms the safety and efficacy of collagenase C. histolyticum therapy in men with Peyronie's disease. Intralesional collagenase C. histolyticum for Peyronie's disease according to the IMPRESS (Investigation of Maximal Peyronie's Reduction Efficacy and Safety Studies) trial protocol produced an improvement in penile curvature in men with Peyronie's disease with a low rate of complications. |
| Databáze: | OpenAIRE |
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