Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution
| Autor: | Cécile Breyton, Ange Polidori, Florence Lebaupain, Jean-Luc Popot, Bernard Pucci, Marc Presset, Bruno Ameduri |
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| Přispěvatelé: | Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels (LCBOSMV), Avignon Université (AU), Physico-chimie moléculaire des membranes biologiques (PCMMB), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Systèmes d'Information Chimique (LSIC - ENSCM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS), collaboration universitaire informelle, Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Aggregates
Double bond Hydrocarbons Fluorinated Protein Conformation Surface Properties Clinical Biochemistry Disaccharide Pharmaceutical Science 01 natural sciences Biochemistry 03 medical and health sciences chemistry.chemical_compound Surface-Active Agents Pulmonary surfactant Drug Discovery Membrane proteins Native state Solubilization Organic chemistry Fluorocarbon Maltose Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Maltoside Aqueous solution 010405 organic chemistry Organic Chemistry Free-radical reaction Water Combinatorial chemistry 0104 chemical sciences [CHIM.POLY]Chemical Sciences/Polymers chemistry Membrane protein Molecular Medicine Fluorinated surfactants |
| Zdroj: | Bioorganic and Medicinal Chemistry Letters Bioorganic and Medicinal Chemistry Letters, Elsevier, 2006, 16, pp.5827-5831. ⟨10.1016/j.bmcl.2006.08.070⟩ Bioorganic and Medicinal Chemistry Letters, 2006, 16, pp.5827-5831. ⟨10.1016/j.bmcl.2006.08.070⟩ |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2006.08.070⟩ |
| Popis: | International audience; Two novel fluorinated surfactants have been obtained by grafting by radical reaction either a fluorocarbon or an ethyl end-capped fluorocarbon chain onto the double bond of b-D-allyl maltose. The two compounds thus obtained form polydisperse aggregates in water. They can keep membrane proteins water-soluble, but the protein/surfactant complexes are polydisperse, which affects neither the native state nor the stability of the proteins. |
| Databáze: | OpenAIRE |
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