Eight Years of Growth Hormone Treatment in Children With Prader-Willi Syndrome
| Autor: | E. Van Pinxteren-Nagler, van Maria Leeuwen, Danny A. J. P. Haring, Joost Rotteveel, H. Van Wieringen, R. J. Odink, M. A. J. de Ridder, J. J. G. Hoorweg-Nijman, N. E. Bakker, A. A. E. M. Van Alfen, Gianni Bocca, G. C. B. (Karen) Bindels-de Heus, Rene C. F. M. Vreuls, E J Schroor, Dederieke A. M. Festen, Nitash Zwaveling-Soonawala, R. J. Kuppens, Euphemia C. A. M. Houdijk, L. Lunshof, Elbrich P. C. Siemensma, R. F. A. Tummers-de Lind van Wijngaarden, Anita C. S. Hokken-Koelega, Petr E. Jira, Wilma Oostdijk |
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| Přispěvatelé: | Pediatric surgery, ICaR - Circulation and metabolism, Faculteit Medische Wetenschappen/UMCG, Pediatrics, Psychiatry, Epidemiology, APH - Amsterdam Public Health, Obstetrics and Gynaecology, Other Research, Paediatric Endocrinology |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty BODY-COMPOSITION Adolescent DISORDERS Endocrinology Diabetes and Metabolism Clinical Biochemistry CHILDHOOD METABOLISM Biochemistry THERAPY law.invention Absorptiometry Photon Endocrinology Randomized controlled trial Bone Density law Internal medicine ADOLESCENTS Humans Medicine Obesity Prospective Studies Child Prospective cohort study Human Growth Hormone business.industry Biochemistry (medical) RANDOMIZED CONTROLLED-TRIAL medicine.disease Body Height PREVALENCE Growth hormone treatment DEFICIENCY Somatropin Treatment Outcome Blood pressure Child Preschool Body Composition Disease Progression Lean body mass RISK-FACTORS Female business Prader-Willi Syndrome Body mass index |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 98(10), 4013-4022. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 98(10), 4013-4022. ENDOCRINE SOC Bakker, N E, Kuppens, R J, Siemensma, E P C, van Wijngaarden, R F A T, Festen, D A M, van Bindels-de Heus, G C B, Bocca, G, Haring, D A J P, Hoorweg-Nijman, J J G, Houdijk, E C A M, Jira, P E, Lunshof, L, Odink, R J, Oostdijk, W, Rotteveel, J, Schroor, E J, Van Alfen, A A E M, van Leeuwen, M, van Pinxteren-Nagler, E, van Wieringen, H, Vreuls, R C F M, Zwaveling-Soonawala, N, de Ridder, M A J & Hokken-Koelega, A C S 2013, ' Eight Years of Growth Hormone Treatment in Children With Prader-Willi Syndrome: Maintaining the Positive Effects ', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 10, pp. 4013-4022 . https://doi.org/10.1210/jc.2013-2012 Journal of Clinical Endocrinology and Metabolism, 98(10), 4013-4022. Endocrine Society Journal of clinical endocrinology and metabolism, 98(10), 4013-4022. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 98(10), 4013-4022 |
| ISSN: | 0021-972X |
| DOI: | 10.1210/jc.2013-2012 |
| Popis: | Background: The most important reason for treating children with Prader-Willi syndrome (PWS) with GH is to optimize their body composition.Objectives: The aim of this ongoing study was to determine whether long-term GH treatment can counteract the clinical course of increasing obesity in PWS by maintaining the improved body composition brought during early treatment.Setting: This was a multicenter prospective cohort study.Methods: We have been following 60 prepubertal children for 8 years of continuous GH treatment (1 mg/m(2)/d congruent to 0.035 mg/kg/d) and used the same dual-energy x-ray absorptiometry machine for annual measurements of lean body mass and percent fat.Results: After a significant increase during the first year of GH treatment (P Conclusion: This 8-year study demonstrates that GH treatment is a potent force for counteracting the clinical course of obesity in children with PWS. |
| Databáze: | OpenAIRE |
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