Infectious and inflammatory disorders might increase the risk of developing idiopathic intracranial hypertension - a national case-control study
| Autor: | Elisabet Waldenlind, Anna Sundholm, A Ingela M Nilsson Remahl, Shahram Bahmanyar, Sarah Burkill |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty case-control study Inflammation Newly diagnosed Pseudotumor cerebri syndrome Infections 03 medical and health sciences 0302 clinical medicine Medicine Humans risk factors 030212 general & internal medicine Aged Retrospective Studies Sweden Pseudotumor Cerebri business.industry Incidence Case-control study General Medicine Original Articles Middle Aged infection Increased risk Case-Control Studies benign intracranial hypertension Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Cephalalgia |
| ISSN: | 1468-2982 |
| Popis: | Objective To investigate whether conditions causing inflammatory activation are associated with increased risk of idiopathic intracranial hypertension. Methods All newly diagnosed idiopathic intracranial hypertension patients (cases) in Sweden between 2000–2016 were identified using pre-determined algorithms (n = 902) and matched with five controls from the general population and five individuals with an obesity diagnosis (n = 4510) for age, sex, region, and vital status. National health registers provided information on infections, inflammatory disorders and dispensed medications. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. Results Compared to general population controls, the cases had fourfold increased odds of having an infection (odds ratio = 4.3, 95% confidence interval 3.3–5.6), and threefold increased odds of an inflammatory disorder the year prior to idiopathic intracranial hypertension diagnosis (odds ratio = 3.2, 95% confidence interval 2.4–4.3). Organ specific analyses showed that odds were increased for the study diseases in the respiratory organ, kidney organ and gastrointestinal tract, but not for female genital infections. Similar results were found when comparing idiopathic intracranial hypertension with obese controls though the odds ratios were of lower magnitude. Sub-analyses on exposure to anti-infectious and anti-inflammatory drugs confirmed the increased odds ratios for idiopathic intracranial hypertension patients. Conclusions These findings suggest that major inflammatory activation may be a risk factor in idiopathic intracranial hypertension development. |
| Databáze: | OpenAIRE |
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