Calcium kinetics in the hyperprostaglandin E syndrome
| Autor: | Thomas R. Welch, Steven A. Abrams, Nancy E. Vieira, Lawrence R. Shoemaker, Alfred L. Yergey, William H Bergstrom |
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| Rok vydání: | 1993 |
| Předmět: |
Calcium Isotopes
Male medicine.medical_specialty Calcitriol Bone density medicine.medical_treatment Indomethacin chemistry.chemical_element Calcium Isotopes of calcium Excretion Bone Density Internal medicine medicine Humans Hypercalciuria Child Chemistry Prostaglandins E Syndrome medicine.disease Urinary calcium Calcium Dietary Kinetics Nephrocalcinosis Endocrinology Child Preschool Pediatrics Perinatology and Child Health Prostaglandin E medicine.drug |
| Zdroj: | Pediatric research. 33(1) |
| ISSN: | 0031-3998 |
| Popis: | Metabolic investigations, including the use of stable isotopes of calcium, were used to study calcium kinetics in three children with the hyperprostaglandin E syndrome. The studies were performed both during indomethacin treatment and in the absence of therapy. Off therapy, each child had hypercalciuria (mean urinary calcium excretion 0.478 mM/kg/d), hyperprostaglandinuria, and elevated serum calcitriol concentration. All had diminished bone density and were euparathyroid. Indomethacin treatment was associated with a marked reduction in serum calcitriol concentration, as well as decreased prostaglandin E excretion. Mean urinary calcium excretion fell to 0.135 mM/kg/d. The stable isotope studies defined two components to the hypercalciuria of this disease: an indomethacin-sensitive dietary contribution and a relatively indomethacin-resistant bone resorptive element. Bone densitometry confirmed the presence of the resorptive element by demonstrating skeletal demineralization. |
| Databáze: | OpenAIRE |
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