Ibuprofen lowers body temperature and metabolic rate of humans with burn injury
| Autor: | John B. Cone, Wallace Bh, Fred T. Caldwell |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Burn injury
medicine.medical_specialty Adolescent Nitrogen Ibuprofen Calorimetry Critical Care and Intensive Care Medicine Degree (temperature) Body Temperature Degree Celsius medicine Humans Child Thermal injury business.industry organic chemicals Rectal temperature Crossover study Surgery Anesthesia Metabolic rate Basal Metabolism business Burns medicine.drug |
| Zdroj: | The Journal of trauma. 32(2) |
| ISSN: | 0022-5282 |
| Popis: | A group of 15 burned children and young adults with large burns (mean, 41% +/- 15% BSA) were administered ibuprofen (40 mg/kg for 3 days). Each patient served as his or her own control in this crossover study (with and without ibuprofen). Paired calorimetric and temperature studies and urinary nitrogen measurements were performed. No nitrogen-sparing effect was identified for this dose of ibuprofen. However, patients demonstrated a statistically significant reduction in average rectal temperature (0.67 degrees C decreases) (p less than 0.01) and in metabolic rate (11.4% decreases) (p less than 0.01) while taking ibuprofen. Linear regression analysis of the reduction in temperature versus the reduction in metabolic rate yielded a statistically significant correlation (p less than 0.01) with a slope of 13.6% reduction in metabolic rate per degree centigrade reduction in the 72-hour average rectal temperature. These results support the hypothesis that ibuprofen attenuates the hypermetabolic response to thermal injury by blunting the temperature elevation that is usually seen. |
| Databáze: | OpenAIRE |
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