The incidence of cytomegalovirus infection in lung transplant recipients under universal prophylaxis with intravenous ganciclovir
| Autor: | Sadi Marcelo Schio, Teresa C. Sukkienik, Tatiana Michelon, Leticia Sanchez, João Wurdig, Alessandro C. Pasqualotto, Regina Barbosa Schroeder, Jorge Neumann, I Fagundes, José de Jesus Peixoto Camargo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Microbiology (medical) Ganciclovir medicine.medical_specialty Adolescent ganciclovir medicine.medical_treatment antigenemia lcsh:QR1-502 Congenital cytomegalovirus infection Cytomegalovirus Azathioprine Antiviral Agents lcsh:Microbiology lcsh:Infectious and parasitic diseases Cohort Studies Immunocompromised Host Postoperative Complications Prednisone Internal medicine lung transplantation medicine Humans Lung transplantation lcsh:RC109-216 Child Infusions Intravenous Aged Retrospective Studies Lung business.industry Incidence Incidence (epidemiology) virus diseases Middle Aged medicine.disease Surgery surgical procedures operative Infectious Diseases medicine.anatomical_structure Cytomegalovirus Infections Female prophylaxis business Serostatus medicine.drug |
| Zdroj: | Brazilian Journal of Infectious Diseases, Vol 11, Iss 2, Pp 212-214 Brazilian Journal of Infectious Diseases v.11 n.2 2007 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 11, Issue: 2, Pages: 212-214, Published: APR 2007 |
| ISSN: | 1413-8670 |
| DOI: | 10.1590/s1413-86702007000200008 |
| Popis: | The best strategy for control of cytomegalovirus (CMV) infection in lung transplant patients is still not determined. The aim of this study was to document the incidence of CMV infection in a cohort of lung transplant recipients under universal prophylaxis with intravenous ganciclovir. All patients received immunosuppressive regimens consisting of cyclosporine, azathioprine, and prednisone. Regardless of CMV serostatus, intravenous ganciclovir was prescribed for every patient in the first 3 months post-transplantation. CMV infection was defined as the detection of CMV pp65 in leukocytes. Eighty-two lung transplant patients were included over a 5-year period. The incidence of CMV infection in the first year post-transplantation was 68.3%, occurring after a median length of 114 days (range, 26-343 days). This study revealed a high incidence of CMV infection in the first year following lung transplantation despite prolonged universal ganciclovir prophylaxis. |
| Databáze: | OpenAIRE |
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