Repeated Supramaximal Exercise-Induced Oxidative Stress: Effect of β-Alanine Plus Creatine Supplementation
| Autor: | Serdar Balci, Serkan Revan, Muaz Belviranli, Nilsel Okudan, Hakkı Gökbel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.medical_treatment Carnosine beta-Alanine Creatine medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Orthopedics and Sports Medicine Beta-Alanine business.industry 030229 sport sciences Glutathione Malondialdehyde Oxidative Stress 030104 developmental biology Endocrinology chemistry Biochemistry Circuit-Based Exercise business Oxidative stress Research Article |
| Zdroj: | Asian Journal of Sports Medicine |
| ISSN: | 2008-7209 2008-000X |
| Popis: | Background Carnosine is a dipeptide formed from the β-alanine and histidine amino acids and found in mainly in the brain and muscle, especially fast twitch muscle. Carnosine and creatine has an antioxidant effect and carnosine accounts for about 10% of the muscle's ability to buffer the H(+) ions produced by exercise. Objectives The aim of the study was to investigate the effects of beta alanine and/or creatine supplementation on oxidant and antioxidant status during repeated Wingate tests (WTs). Patients and methods Forty four sedentary males participated in the study. Participants performed three 30s WTs with 2 minutes rest between exercise bouts. After the first exercise session, the subjects were assigned to one of four groups: Placebo, Creatine, Beta-alanine and Beta-alanine plus creatine. Participants ingested twice per day for 22 consecutive days, then four times per day for the following 6 days. After the supplementation period the second exercise session was applied. Blood samples were taken before and immediately after the each exercise session for the analysis of oxidative stress and antioxidant markers. Results Malondialdehyde levels and superoxide dismutase activities were affected by neither supplementation nor exercise. During the pre-supplementation session, protein carbonyl reduced and oxidized glutathione (GSH and GSSG) levels increased immediately after the exercise. However, during the post-supplementation session GSH and GSSG levels increased in beta-alanine and beta-alanine plus creatine groups immediately after the exercise compared to pre-exercise. In addition, during the post-supplementation session total antioxidant capacity increased in beta-alanine group immediately after the exercise. Conclusions Beta-alanine supplementation has limited antioxidant effect during the repeated WTs. |
| Databáze: | OpenAIRE |
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