Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of Akt
| Autor: | Ritis K. Shyanti, Jyoti Tak, Rana P. Singh, Akash Sabarwal |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cyclin-Dependent Kinase Inhibitor p21
0301 basic medicine Cyclin E Berberine Clinical Biochemistry Down-Regulation Breast Neoplasms Cycloheximide Gene Expression Regulation Enzymologic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cyclin D1 Humans neoplasms Molecular Biology Protein kinase B biology Protein Stability Kinase Cyclin-dependent kinase 2 Cell Biology General Medicine Gene Expression Regulation Neoplastic 030104 developmental biology chemistry 030220 oncology & carcinogenesis MCF-7 Cells biology.protein Cancer research Female Cyclin-dependent kinase 6 biological phenomena cell phenomena and immunity Proto-Oncogene Proteins c-akt |
| Zdroj: | Molecular and Cellular Biochemistry. 458:49-59 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-019-03529-4 |
| Popis: | Berberine has shown anticancer properties and has potential for a chemopreventive and/or chemotherapeutic agent for breast cancer. Berberine showed cytotoxicity to breast cancer cells, with an increase in the levels of p21/cip1 and p27/kip1, cyclin-dependent kinase inhibitors (CDKI), but mechanisms involved in up-regulating these molecules are largely unknown. Herein, we studied the key regulatory mechanisms involved in berberine-mediated up-regulation of p21/cip1 and p27/kip1. Berberine treatment for 24 and 48 h decreased the number of cells by 44–84% (P |
| Databáze: | OpenAIRE |
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