The Erythrocytic Hypothesis of Brain Energy Crisis in Sporadic Alzheimer Disease: Possible Consequences and Supporting Evidence
| Autor: | Gubidat Alilova, Lyudmila A. Tikhonova, Elena Kosenko, Carmina Montoliu, Amparo Urios |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Systemic disease
lcsh:Medicine Brain tissue Disease Review 03 medical and health sciences 0302 clinical medicine brain energy crisis medicine Dementia erythrocytic hypothesis 030304 developmental biology 0303 health sciences business.industry lcsh:R Neurodegeneration General Medicine medicine.disease restoration of energy metabolism Drug development amyloid β peptides Etiology Alzheimer's disease business Neuroscience Alzheimer’s disease 030217 neurology & neurosurgery red blood cells |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 1, p 206 (2020) |
| ISSN: | 2077-0383 |
| Popis: | Alzheimer’s disease (AD) is a fatal form of dementia of unknown etiology. Although amyloid plaque accumulation in the brain has been the subject of intensive research in disease pathogenesis and anti-amyloid drug development; the continued failures of the clinical trials suggest that amyloids are not a key cause of AD and new approaches to AD investigation and treatment are needed. We propose a new hypothesis of AD development based on metabolic abnormalities in circulating red blood cells (RBCs) that slow down oxygen release from RBCs into brain tissue which in turn leads to hypoxia-induced brain energy crisis; loss of neurons; and progressive atrophy preceding cognitive dysfunction. This review summarizes current evidence for the erythrocytic hypothesis of AD development and provides new insights into the causes of neurodegeneration offering an innovative way to diagnose and treat this systemic disease. |
| Databáze: | OpenAIRE |
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