Effect of Digital Adherence Tools on Adherence to Antiretroviral Treatment Among Adults Living With HIV in Kilimanjaro, Tanzania: A Randomized Controlled Trial
| Autor: | Mirjam A. G. Sprangers, Rob E. Aarnoutse, Peter Reiss, Tolbert Sonda, Blandina T. Mmbaga, I. Marion Sumari-de Boer, Kennedy Ngowi, Francis Pima, Pythia T. Nieuwkerk, Bpharm Lyidia V. Masika |
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| Přispěvatelé: | APH - Global Health, APH - Health Behaviors & Chronic Diseases, Medical Psychology, APH - Aging & Later Life, APH - Mental Health, Global Health, Infectious diseases, AII - Infectious diseases, AII - Inflammatory diseases, APH - Personalized Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Anti-HIV Agents Reminder Systems Human immunodeficiency virus (HIV) MEDLINE HIV Infections medicine.disease_cause Tanzania real-time medication monitoring Medication Adherence law.invention Young Adult adherence to treatment Randomized controlled trial Standard care law short message service Antiretroviral treatment Humans Medicine Pharmacology (medical) Medication monitoring Aged Implementation Science Text Messaging clinical trials biology business.industry PLHIV Middle Aged biology.organism_classification Clinical trial digital adherence tools lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Infectious Diseases ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Physical therapy Female business |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999), 87(5), 1136-1144. Lippincott Williams and Wilkins JAIDS : Journal of Acquired Immune Deficiency Syndromes, 87, 1136-1144 Journal of Acquired Immune Deficiency Syndromes (1999) JAIDS : Journal of Acquired Immune Deficiency Syndromes, 87, 5, pp. 1136-1144 |
| ISSN: | 1525-4135 |
| Popis: | Supplemental Digital Content is Available in the Text. Background: Lifelong adherence to antiretroviral treatment remains challenging for people living with HIV (PLHIV). The aim of this study was to investigate whether any of 2 digital adherence tools could improve adherence among PLHIV in Kilimanjaro, Tanzania. Methods: We performed a parallel 3-arm, nonblinded, randomized controlled trial with 1:1:1 allocation. We included adults aged between 18 and 65 years, living in Kilimanjaro region, and who were on antiretroviral treatment for at least 6 months. Their adherence, as judged by the study nurses, had to be suboptimal. In one arm, participants received reminder short message service (SMS) texts, followed by a question SMS. In the second arm, participants received a real-time medication monitoring (RTMM) device (Wisepill) with SMS reminders. In the third arm, participants received standard care only. The primary outcome of mean adherence over 48 weeks was compared between arms using between-group t tests in a modified intention-to-treat analysis. Results: In each arm, we randomized 83 participants: data of 82 participants in the RTMM arm, 80 in the SMS arm, and 81 in the standard care arm were analyzed. The average (over 48 weeks) adherence in the SMS, RTMM, and control arms was 89.6%, 90.6%, and 87.9% for pharmacy refill; 95.9%, 95.0%, and 95.2% for self-report in the past week; and 97.5%, 96.6%, and 96.9% for self-report in the past month, respectively (P values not statistically significant). Conclusions: Receiving reminder SMS or RTMM combined with feedback about adherence levels and discussion of strategies to overcome barriers to adherence did not improve adherence to treatment and treatment outcome in PLHIV. Clinical Trial Number: PACTR201712002844286. |
| Databáze: | OpenAIRE |
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