Patient Case Report: Gabapentin-Induced Hypoglycemia
| Autor: | Abigale Ferdinand, Stephan Neabore, William J Hayes, Joseph Berendse, Katie M Hayes, John A Kappes |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cyclohexanecarboxylic Acids
Gabapentin Sedation 030209 endocrinology & metabolism Hypoglycemia 03 medical and health sciences 0302 clinical medicine medicine Humans Pharmacology (medical) Amines Adverse effect gamma-Aminobutyric Acid business.industry Mechanism (biology) 030206 dentistry Middle Aged medicine.disease Anesthesia Female Calcium Channels medicine.symptom business Somnolence medicine.drug |
| Zdroj: | Journal of Pharmacy Practice. 35:298-301 |
| ISSN: | 1531-1937 0897-1900 |
| Popis: | Purpose: Gabapentin is an analog of gamma-aminobutyric acid (GABA), but its complete mechanism is not well understood. Common adverse effects from gabapentin include somnolence, sedation, and dizziness. Hyperglycemia is listed as a possible adverse drug reaction in the labeling. Case reports describe hypoglycemia in patients with diabetes, peritoneal dialysis, and/or incomplete medication records. The following case report details a hypoglycemia episode as a potential result of a gabapentin use in a patient without diabetes. Summary: A 47-year old, 68 kg, white female presented to the emergency department with altered mental status. Her blood glucose level was 33 mg/dL. Gabapentin was started 1 week prior to the hypoglycemia episode. Her past medical history, concomitant medications, and other laboratory findings were not likely causes of her severe hypoglycemia. Conclusion: Gabapentin appears to have effects on several voltage-gated calcium channels. Hypoglycemia may be due to gabapentin binding to the alpha2delta subunit of the calcium channels in the pancreas. Future research should investigate gabapentin and the potential for hypoglycemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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