Intralesional Injection of Hyaluronic Acid in Patients Affected With Peyronie's Disease: Preliminary Results From a Prospective, Multicenter, Pilot Study
Autor: | T. Tony Cai, Giuseppe D'Achille, Vincenzo Favilla, Elisabetta Costantini, Alessandro Palmieri, Vincenzo Mirone, Alessandro Zucchi, Giovanni Liguori, Giorgio Cavallini, Giorgio Franco, Gaetano De Grande, Paolo Verze, Mauro Silvani |
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Přispěvatelé: | Zucchi, Alessandro, Costantini, Elisabetta, Cai, Tommaso, Cavallini, Giorgio, Liguori, Giovanni, Favilla, Vincenzo, De Grande, Gaetano, D'Achille, Giuseppe, Silvani, Mauro, Franco, Giorgio, Palmieri, Alessandro, Verze, Paolo, Mirone, Vincenzo |
Rok vydání: | 2016 |
Předmět: |
Hyaluronic Acid
Intralesional Therapy Penile Curvature Peyronie's Disease Reproductive Medicine 2708 Urology Behavioral Neuroscience medicine.medical_specialty Endocrinology Diabetes and Metabolism education 030232 urology & nephrology lcsh:Medicine Inflammation Dermatology medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Hyaluronic acid medicine In patient Original Research 030219 obstetrics & reproductive medicine business.industry lcsh:R lcsh:Other systems of medicine lcsh:RZ201-999 medicine.disease Surgery Psychiatry and Mental health chemistry Penile curvature medicine.symptom Peyronie's disease business Oxidative stress |
Zdroj: | Sexual Medicine Sexual Medicine, Vol 4, Iss 2, Pp e85-e90 (2016) |
ISSN: | 2050-1161 |
DOI: | 10.1016/j.esxm.2016.01.002 |
Popis: | Introduction Hyaluronic acid has been shown to be efficacious in decreasing scar formation, inflammation, and oxidative stress. Aim To assess the efficacy of intralesional injection of hyaluronic acid in patients affected by Peyronie's disease. Methods In this prospective, single-arm, self-controlled, interventional, multicenter pilot study, 65 patients underwent a 10-week cycle of weekly intraplaque injections with hyaluronic acid (0.8% highly purified sodium salt hyaluronic acid 16 mg/2 mL; Sinovial, IBSA, Lodi, Italy). Patients were re-evaluated 2 months after the end of therapy. Main Outcome Measures Plaque size (millimeters), penile curvature (degrees), International Index of Erectile Function (IIEF-5) score, visual analog scale (VAS) score for sexual satisfaction, and Patient's Global Impressions of Improvement (PGI-I) score. Results Median age was 57 years (range = 23–70). At baseline, mean plaque size was 10 mm (range = 3–30 mm), mean penile curvature was 30° (range = 0°–50°), and mean IIEF-5 score was 20 (range = 0–25), with slight to moderate erectile dysfunction (IIEF score < 21) in 36 of 65 patients (55%). A median VAS score of 6 (range = 2–10) was found. Mean follow-up was 12 months (range = 6–24 months). Statistically significant post-treatment improvements were detected for plaque size (before treatment = 10 mm [3–30 mm], after treatment = 8 mm [1–30 mm], P < .0001), penile curvature (before treatment = 30° [0°–50°], after treatment = 20° [0°–40°], P < .0001), IIEF-5 score (before treatment = 20 [11–25], after treatment = 21 [15–25], P < .0001), and VAS score (before treatment = 6 [2–10], after treatment 8 [2–10], P < .0001). After treatment, the rate of patients with an IIEF score lower than 21 decreased from 55% (36 patients) to 40% (25 patients). Overall improvement on the PGI-I questionnaire was 69%. Conclusion Intralesional treatment with hyaluronic acid can improve plaque size, penile curvature, and overall sexual satisfaction and seems preferably indicated in the early (active) phase of the disease. Furthermore, it is easy to perform and well tolerated. |
Databáze: | OpenAIRE |
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