Clinical significance of transmembrane 4 superfamily in colon cancer
| Autor: | Seiji Satoh, Yoshio Yamaoka, A Takabayashi, Toshihiko Taki, Nobuaki Kobayashi, Noboru Hattori, Takahiro Tokuhara, Hitoshi Hasegawa, Hiroki Hashida, Masayuki Miyake |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty MRP-1/CD9 Tumor suppressor gene Survival Colorectal cancer Biology Tetraspanin 24 Gastroenterology Metastasis Antigens CD Antigens Neoplasm Cell Movement Internal medicine medicine Biomarkers Tumor Humans Clinical significance CD151 Aged Retrospective Studies KAI1/CD82 Molecular and Cellular Pathology Membrane Proteins Middle Aged medicine.disease Prognosis Reverse transcriptase Gene Expression Regulation Neoplastic Oncology colon cancer TM4SF Colonic Neoplasms Cancer research Immunohistochemistry Female CD82 |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Cell motility is an important cellular function closely related to the processes of tumour progression and metastasis. Several members of transmembrane 4 superfamily (TM4SF) have been reported to be associated with cell motility and metastatic potential of solid tumour. The aim of this study is to clarify the clinical significance of the member of TM4SF (MRP-1/CD9, KAI1/CD82 and CD151) in human colon cancer. We studied 146 colon cancer patients who underwent curative surgery and studied the expression of MRP-1/CD9, KAI1/CD82 and CD151 using reverse transcriptase – polymerase chain reaction and immunohistochemistry. We found that 64 patients (43.8%) had MRP-1/CD9-positive tumours and that the overall survival rate of patients with MRP-1/CD9-positive tumours was much higher than that of patients with MRP-1/CD9-negative tumours (89.8 vs 50.8%, P |
| Databáze: | OpenAIRE |
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