Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method
Autor: | Elzbieta Pietrzykowska, Maciej Lojkowski, Bartosz Woźniak, Damian Fudala, Urszula Szałaj, Witold Lojkowski, Monika Bil, Anna Swiderska-Sroda, Barbara Sokołowska, Justyna Nasiłowska, Khaled AbouAitah, Wojciech Swieszkowski |
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Rok vydání: | 2021 |
Předmět: |
Materials science
General Chemical Engineering antibacterial coating Nanoparticle cefuroxime sodium salt antibiotic 02 engineering and technology 010402 general chemistry 01 natural sciences Article hydroxyapatite nanoparticles Polyether ether ketone chemistry.chemical_compound Peek General Materials Science QD1-999 drug release PEEK implants Staphylococcus aureus bacteria Substrate (chemistry) sonocoating 021001 nanoscience & nanotechnology 0104 chemical sciences Chemistry Chemical engineering chemistry Implant 0210 nano-technology Antibacterial activity Layer (electronics) Cefuroxime Sodium |
Zdroj: | Nanomaterials Volume 11 Issue 7 Nanomaterials, Vol 11, Iss 1690, p 1690 (2021) |
ISSN: | 2079-4991 |
Popis: | Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against Staphylococcus aureus. We achieved a concentration of up to 1 mg of drug per cm2 of the coated substrate. In drug release tests, an initial burst was observed within 24 h, accompanied by a linear stable release effect. The drug-loaded implants exhibited sufficient activity against S. aureus for 24 and 168 h. Thus, the simple method we present here produces a biocompatible coating that can be soaked with antibiotics for antibacterial properties and can be used for a range of medical implants. |
Databáze: | OpenAIRE |
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