Molecular Insight into the Binding Property and Mechanism of Sulfamethoxazole to Extracellular Proteins of Anammox Sludge

Autor:	Gui-Feng Li, Wen-Jie Ma, Zhi-Qi Ren, Ye Wang, Jing-Peng Li, Jia-Wen Zhao, Shu-Ting Li, Qi Liu, Ye-Nan Gu, Ya-Fei Cheng, Bao-Cheng Huang, Ren-Cun Jin
Rok vydání:	2021
Předmět:	Molecular Docking Simulation Bioreactors Sewage Sulfamethoxazole Nitrogen Ammonium Compounds Environmental Chemistry Anaerobiosis General Chemistry Oxidation-Reduction Anaerobic Ammonia Oxidation
Zdroj:	Environmental Science & Technology. 55:16627-16635
ISSN:	1520-5851 0013-936X
DOI:	10.1021/acs.est.1c05203
Popis:	Antibiotics are widely found in nitrogen-containing wastewater, which may affect the operation stability of anaerobic ammonium oxidation (anammox)-based biological treatment systems. Extracellular polymeric substances (EPSs) of anammox sludge play a pivotal role in combining with antibiotics; however, the exact role and how the structure of the leading component of EPSs (i.e., extracellular proteins) changes under antibiotic stress remain to be elucidated. Here, the interaction between sulfamethoxazole and the extracellular proteins of anammox sludge was investigated via multiple spectra and molecular simulation. Results showed that sulfamethoxazole statically quenched the fluorescent components of EPSs, and the quenching constant of the aromatic proteins was the largest, with a value of 1.73 × 10
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7974a1df1c990e4e55e741cc523ebb26 https://doi.org/10.1021/acs.est.1c05203 Zobrazit plný text záznamu