β-arrestin 2-mediated immune suppression induced by chronic stress
| Autor: | Avani Javer, Gregory Hanley, Dean Andrew Smalligan, Hui Li, Nanchang Xie, Deling Yin, Yi Zhang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
genetic structures Arrestins medicine.medical_treatment Immunology Biology Beta-Arrestin-2 Immune tolerance Mice Endocrinology Immune system medicine Splenocyte Immune Tolerance Animals Chronic stress PI3K/AKT/mTOR pathway beta-Arrestins Mice Knockout Original Paper Endocrine and Autonomic Systems Beta-Arrestins Immunosuppression beta-Arrestin 2 Mice Inbred C57BL Disease Models Animal Neurology Chronic Disease sense organs Stress Psychological |
| Zdroj: | Neuroimmunomodulation. 18(3) |
| ISSN: | 1423-0216 |
| Popis: | Objective: Stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced immune suppression remain to be elucidated. β-Arrestin 2 serves as adaptor, scaffold, and/or signal transducer. The role of β-arrestin 2 in stress-induced immune suppression is not known yet. Methods/Results: Here, we demonstrate that β-arrestin 2 deficiency in mice increases the sensitivity to the chronic stress-induced reduction in the number of splenocytes. Interestingly, the stress-induced suppression of T helper-type (Th) 1 cytokines and the increased production of Th2 cytokines were greatly enhanced in β-arrestin 2-deficient mice compared with wild-type mice. Moreover, inhibition of PI3K in β-arrestin 2-deficient mice exerts an additive effect on the stress-induced reduction in the number of splenocytes. Conclusion: Our study demonstrates that a deficiency in β-arrestin 2 augments stress-induced immune suppression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|