Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging
| Autor: | Andrea G. Brear, Julie Kennedy, Lauren Tereshko, Astrid Cornils, Ashish K. Maurya, Piali Sengupta, Veena Prahlad, Oliver E. Blacque |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research biology lcsh:QH426-470 Cilium biology.organism_classification Ciliopathies Cell biology Heat shock factor 03 medical and health sciences lcsh:Genetics 030104 developmental biology 0302 clinical medicine Microtubule Intraflagellar transport Chaperone (protein) Genetics biology.protein sense organs HSF1 Molecular Biology 030217 neurology & neurosurgery Genetics (clinical) Ecology Evolution Behavior and Systematics Caenorhabditis elegans |
| Zdroj: | PLoS Genetics, Vol 12, Iss 12, p e1006325 (2016) |
| ISSN: | 1553-7404 1553-7390 |
| Popis: | The majority of cilia are formed and maintained by the highly conserved process of intraflagellar transport (IFT). Mutations in IFT genes lead to ciliary structural defects and systemic disorders termed ciliopathies. Here we show that the severely truncated sensory cilia of hypomorphic IFT mutants in C. elegans transiently elongate during a discrete period of adult aging leading to markedly improved sensory behaviors. Age-dependent restoration of cilia morphology occurs in structurally diverse cilia types and requires IFT. We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone. Our results describe an unexpected role of early aging and protein quality control mechanisms in suppressing ciliary phenotypes of IFT mutants, and suggest possible strategies for targeting subsets of ciliopathies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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