Developing OECD test guidelines for regulatory testing of nanomaterials to ensure mutual acceptance of test data
| Autor: | Peter Kearns, Kirsten Rasmussen, Hubert Rauscher, Mar González, Juan Riego Sintes |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Computer science
Guidance documents Environmental media General Medicine 010501 environmental sciences Toxicology 030226 pharmacology & pharmacy 01 natural sciences Article Test (assessment) Nanostructures Manufactured nanomaterials 03 medical and health sciences 0302 clinical medicine Risk analysis (engineering) Physical chemical Administration Inhalation Toxicity Tests Animals Humans Organisation for Economic Co-Operation and Development 0105 earth and related environmental sciences Test data |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 104 |
| ISSN: | 1096-0295 |
| Popis: | The OECD Working Party on Manufactured Nanomaterials (WPMN) provides a global forum for discussion of nano-safety issues. Together with the OECD Test Guidelines Programme (TGP) the WPMN has explored the need for adaptation of some of the existing OECD Test Guidelines (TGs) and Guidance Documents (GDs) as well as developing new TGs and GDs to specifically address NM issues. An overview is provided of progress in the TGP and WPMN, and information on supporting initiatives, regarding the development of TGs for nanomaterials addressing Physical Chemical Properties, Effects on Biotic Systems, Environmental Fate and Behaviour, and Health Effects. Three TGs specifically addressing manufactured nanomaterials have been adopted: a new TG318 ″Dispersion Stability of Nanomaterials in Simulated Environmental Media", and adaptation of TG412 and TG413 on Subacute Inhalation Toxicity: 28-Day Study/90-day Study. The associated GD39 on Inhalation Toxicity Testing has also been revised. The TGP current develops four new TGs and four GDs. One new TG and six GDs are developed in the WPMN. Six new proposals were submitted to the TGP in 2018. Furthermore, as TGs are accompanied by OECD harmonised templates (OHTs) for data collection, an outline of recently developed OHTs particularly relevant for NMs is also included. |
| Databáze: | OpenAIRE |
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