Gelatin porous scaffolds fabricated using a modified gas foaming technique: Characterisation and cytotoxicity assessment
| Autor: | S. Ali Poursamar, Cláudia Lobato da Silva, Javad Hatami, A.P.M. Antunes, Alexander N Lehner, Frederico Castelo Ferreira |
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| Rok vydání: | 2015 |
| Předmět: |
Gas foaming
Materials science food.ingredient Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences Gelatin Cell Line Biomaterials chemistry.chemical_compound Mice food Tissue engineering Materials Science(all) Tensile Strength Ultimate tensile strength Spectroscopy Fourier Transform Infrared Animals Composite material Porosity Cytotoxicity Mechanical Phenomena Tissue Engineering Tissue Scaffolds Mechanical Engineering Temperature Fibroblasts 021001 nanoscience & nanotechnology Condensed Matter Physics Porous scaffold 0104 chemical sciences Cross-Linking Reagents chemistry Glutaral Mechanics of Materials Glutaraldehyde 0210 nano-technology |
| Zdroj: | Materials Science and Engineering: C. 48:63-70 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2014.10.074 |
| Popis: | The current study presents an effective and simple strategy to obtain stable porous scaffolds from gelatin via a gas foaming method. The technique exploits the intrinsic foaming ability of gelatin in the presence of CO2 to obtain a porous structure stabilised with glutaraldehyde. The produced scaffolds were characterised using physical and mechanical characterisation methods. The results showed that gas foaming may allow the tailoring of the 3-dimensional structure of the scaffolds with an interconnected porous structure. To assess the effectiveness of the preparation method in mitigating the potential cytotoxicity risk of using glutaraldehyde as a crosslinker, direct and in-direct cytotoxicity assays were performed at different concentrations of glutaraldehyde. The results indicate the potential of the gas foaming method, in the preparation of viable tissue engineering scaffolds. |
| Databáze: | OpenAIRE |
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