Skin biomarkers predict development of atopic dermatitis in infancy
Autor: | Maria Rasmussen Rinnov, Anne‐Sofie Halling, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Susan M. I. Goorden, Karen J. M. Ghauharali‐van der Vlugt, Femke S. Stet, Lone Skov, Simon Francis Thomsen, Alexander Egeberg, Aske L. L. Rosted, Troels Petersen, Ivone Jakasa, Christoph Riethmüller, Sanja Kezic, Jacob P. Thyssen |
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Přispěvatelé: | AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Laboratory Genetic Metabolic Diseases, Public and occupational health, AII - Infectious diseases, APH - Personalized Medicine, APH - Societal Participation & Health |
Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: |
atopic dermatitis
SPHINGOID BASES Immunology LEVEL STRATUM-CORNEUM ECZEMA birth cohort prediction QUANTIFICATION DEGRADATION SERINE PALMITOYLTRANSFERASE BARRIER FUNCTION Immunology and Allergy FILAGGRIN biomarker skin barrier PHYTOSPHINGOSINE atopic dermatitis biomarker birth cohort prediction skin barrier |
Zdroj: | Allergy: European Journal of Allergy and Clinical Immunology. Wiley-Blackwell Rinnov, M R, Halling, A-S, Gerner, T, Ravn, N H, Knudgaard, M H, Trautner, S, Goorden, S M, Ghauharali-van der Vlugt, K J M, Stet, F S, Skov, L, Thomsen, S F, Egeberg, A, Rosted, A L L, Petersen, T, Jakasa, I, Riethmuller, C, Kezic, S & Thyssen, J P 2023, ' Skin biomarkers predict development of atopic dermatitis in infancy ', Allergy, vol. 78, no. 3, pp. 791-802 . https://doi.org/10.1111/all.15518 |
ISSN: | 0105-4538 |
Popis: | Background There is currently no insight into biomarkers that can predict the onset of pediatric atopic dermatitis (AD). Methods Nested in a prospective birth cohort study that examined the occurrence of physician-diagnosed AD in 300 children, 44 random children with onset of AD in the first year of life were matched on sex and season of birth with 44 children who did not develop AD. Natural moisturizing factor (NMF), corneocyte surface protrusions, cytokines, free sphingoid bases (SBs) of different chain lengths and their ceramides were analyzed from tape strips collected at 2 months of age before onset of AD using liquid chromatography, atomic force microscopy, multiplex immunoassay, and liquid chromatography mass spectrometry, respectively. Results Significant alterations were observed for four lipid markers, with phytosphingosine ([P]) levels being significantly lower in children who developed AD compared with children who did not (median 240 pmol/mg vs. 540 pmol/mg, p < 0.001). The two groups of children differed in the relative amounts of SB of different chain lengths (C17, C18 and C20). Thymus- and activation-regulated chemokine (TARC/CCL17) was slightly higher in children who developed AD, whereas NMF and corneocyte surface texture were similar. AD severity assessed by the eczema area and severity index (EASI) at disease onset was 4.2 (2.0;7.2). [P] had the highest prediction accuracy among the biomarkers (75.6%), whereas the combination of 5 lipid ratios gave an accuracy of 89.4%. Conclusion This study showed that levels and SB chain length were altered in infants who later developed AD, and that TARC/CCL17 levels were higher. |
Databáze: | OpenAIRE |
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