Infralimbic cortex controls the activity of the hypothalamus-pituitary adrenal axis and the formation of aversive memory: effects of environmental enrichment
| Autor: | Giacomo Ronzoni, Alberto Del Arco, María Antón, Francisco Mora, Gregorio Segovia |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Hypothalamo-Hypophyseal System Infralimbic cortex Emotions Neurociencias Pituitary-Adrenal System Environment Motor Activity 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Corticosterone Memory Internal medicine medicine Avoidance Learning Animals Picrotoxin Rats Wistar Prefrontal cortex Cerebral Cortex Environmental enrichment GABAA receptor Muscimol Housing Animal Disease Models Animal 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Cerebral cortex Neuroscience 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid E-Prints Complutense. Archivo Institucional de la UCM instname |
| Popis: | The aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABAA antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone. These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|