Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma
| Autor: | Chuang Rung Chang, Hui Chun Chen, Hung Chen Wang, Teng Yeow Tan, Chih-Yen Chien, Wen Neng Chang, Yu-Jih Su, Hsueh-Wen Chang, Cheng-Hsien Lu, Chih-Cheng Huang, Wei Che Lin, Nai Wen Tsai, Tai-Lin Huang, Hsuan Chih Hsu, Fu-Min Fang, Hsin Ching Lin, Chia Te Kung, Ya-Ting Chang, Chi Ren Huang, Ben Chung Cheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Carotid Artery Diseases
Male Pathology medicine.medical_specialty Carotid Artery Common medicine.medical_treatment Nasopharyngeal neoplasm Carotid Intima-Media Thickness medicine Humans Radiology Nuclear Medicine and imaging In patient cardiovascular diseases Prospective Studies Prospective cohort study Radiation Injuries Neoplasm Staging Nasopharyngeal Carcinoma Radiotherapy business.industry Research Carcinoma Case-control study Nasopharyngeal Neoplasms Middle Aged medicine.disease Atherosclerosis Prognosis Carotid artery.common Radiation therapy Nasopharyngeal carcinoma Intima-media thickness Oncology Risk factors Radiology Nuclear Medicine and imaging Case-Control Studies cardiovascular system Disease Progression Female Radiology business Follow-Up Studies |
| Zdroj: | Radiation Oncology (London, England) |
| ISSN: | 1748-717X |
| Popis: | Background Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression of carotid intima-media thickness (IMT) and investigated its relationship with inflammatory markers. Methods One hundred and five NPC patients post-radiotherapy for more than one year and 25 healthy control subjects were examined by B-mode ultrasound for IMT measurement at the far wall of the common carotid artery (CCA). Surrogate markers including lipid profile, HbA1c, and high sensitive C-reactive protein (hs-CRP) were assessed. Results The IMT of CCA was significantly increased in NPC patients and carotid plaque was detected in 38 NPC patients (38/105, 36.2%). Significant risk factors for carotid plaques included age, duration after radiotherapy, and HbA1c levels. Age, duration after radiotherapy, hs-CRP, HbA1c, and platelet count positively correlated with IMT. The cut-off value of age and duration after radiotherapy for the presence of plaque was 52.5 years and 42.5 months, respectively. In NPC subjects, multiple linear regression analysis revealed that age, gender, duration after radiotherapy and platelet counts were independently associated with CCA IMT. After adjustments for age, gender and platelet counts, IMT increased in a linear manner with duration after radiotherapy. Conclusions Radiation-induced vasculopathy is a dynamic and progressive process due to late radiation effects. Extra-cranial color-coded duplex sonography can be part of routine follow-up in NPC patients aged ≥50 years at 40 months post-radiotherapy. |
| Databáze: | OpenAIRE |
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