Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism
| Autor: | Monika E. Danielewska, Patrycja Krzyżanowska-Berkowska, D. Robert Iskander |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Intraocular pressure Aging Eye Diseases genetic structures Physiology Optic disk Glaucoma Ocular hypertension Cornea Electrocardiography Optic Nerve Diseases Medicine and Health Sciences Medicine Multidisciplinary Middle Aged medicine.anatomical_structure Optic nerve Engineering and Technology Female Glaucoma Angle-Closure Glaucoma Open-Angle Optic disc Research Article Biotechnology medicine.medical_specialty Science Optic Disk Biomedical Engineering Bioengineering Ophthalmology Dicrotic pulse Humans Pulse Intraocular Pressure Aged business.industry Biology and Life Sciences medicine.disease eye diseases Case-Control Studies Signal Processing Visual Field Tests Ocular Hypertension sense organs Visual Fields business Physiological Processes Organism Development Developmental Biology |
| Zdroj: | PLoS ONE, Vol 9, Iss 7, p e102814 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | PurposeTo ascertain whether the incidence of ocular dicrotic pulse (ODP) increases with age, it is more pronounced in glaucomatous than in normal eyes and whether it is related to cardiovascular activity.Methods261 subjects aged 47 to 78 years were included in the study and classified into four groups: primary open angle glaucoma (POAG), primary angle-closure glaucoma (PACG), glaucoma suspects with glaucomatous optic disc appearance (GODA) and the controls (CG). Additionally, in each group, subjects with ODP were divided into two age subgroups around the median age. A non-contact ultrasonic method was used to measure corneal indentation pulse (CIP) synchronically with the acquisition of electrocardiography (ECG) and blood pulse signals. ODP was assessed from the acquired signals that were numerically processed in a custom written program.ResultsODP incidence was about 78%, 66%, 66% and 84% for CG, GODA, POAG, and PACG group, respectively. With advancing age, the ODP incidence increased for all subjects (Δ = 12%), the highest being for the PACG and POAG groups (Δ = 30%). GODA group did not show an age-related increase in the incidence of ODP.ConclusionsThe ocular dicrotism, measured with non-contact ultrasonic method, was found to be a common phenomenon in elderly subjects. The increased ODP incidence in PACG and POAG group may correspond to either higher stiffness of glaucoma eyes, biochemical abnormalities in eye tissues, changes in ocular hemodynamics, may reflect the effect of medications or be a combination of all those factors. The results of GODA group suggest different mechanisms governing their ocular pulse that makes them less susceptible to generating ODP and having decreased predisposition to glaucoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|