Spanish real-world experience with fingolimod in relapsing-remitting multiple sclerosis patients: MS NEXT study
| Autor: | Francisco Barrero, Javier Mallada-Frechin, María Luisa Martínez-Ginés, María Eugenia Marzo, Virginia Meca-Lallana, Guillermo Izquierdo, José Ramón Ara, Celia Oreja-Guevara, José Meca-Lallana, Lucía Forero, Irene Sánchez-Vera, María José Moreno, in representation of the MS NEXT study investigators |
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| Rok vydání: | 2020 |
| Předmět: |
Male
European People Spanish People Pathology and Laboratory Medicine Geographical locations Diagnostic Radiology 0302 clinical medicine Natalizumab Recurrence Medicine and Health Sciences Ethnicities 030212 general & internal medicine Hispanic People Multidisciplinary medicine.diagnostic_test Pharmaceutics Radiology and Imaging Neurodegenerative Diseases Middle Aged Magnetic Resonance Imaging Fingolimod Europe Neurology Research Design Medicine Female Immunosuppressive Agents Research Article medicine.drug Adult medicine.medical_specialty Drug Research and Development Multiple Sclerosis Imaging Techniques Clinical Research Design Science Immunology Research and Analysis Methods Autoimmune Diseases 03 medical and health sciences Signs and Symptoms Multiple Sclerosis Relapsing-Remitting Pharmacotherapy Drug Safety Drug Therapy Diagnostic Medicine Internal medicine medicine Humans Disabled Persons European Union Adverse effect Aged Retrospective Studies Pharmacology Fingolimod Hydrochloride business.industry Multiple sclerosis Biology and Life Sciences Retrospective cohort study Magnetic resonance imaging medicine.disease Demyelinating Disorders Spain Lesions Clinical Immunology Population Groupings Observational study Adverse Events Clinical Medicine People and places business 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE, Vol 15, Iss 4, p e0230846 (2020) PLoS One r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) Zaguán. Repositorio Digital de la Universidad de Zaragoza instname PLoS ONE Zaguán: Repositorio Digital de la Universidad de Zaragoza Universidad de Zaragoza |
| ISSN: | 1932-6203 |
| Popis: | Purpose The objective of this study was to characterize the demographic and clinical profile of RRMS patients receiving fingolimod in Spain, and to evaluate drug effectiveness and safety in clinical practice. Methods This observational, retrospective, multicentre, nationwide study was performed at 56 Spanish hospitals and involved 804 RRMS patients who received oral fingolimod (0.5 mg) since November 2011, with a minimum follow-up of 12 months. Results The mean annualized relapse rate (ARR) in the year before fingolimod was 1.08 and the median EDSS was 3; patients were exposed to fingolimod for 2.2 years as average; regarding magnetic resonance imaging (MRI) activity, more than half of the patients had > 20 lesions at baseline. Patients were previously treated with first-line injectable DMTs (60.3%), or natalizumab (31.3%), and 8.3% were naive patients. Overall, the ARR significantly decreased to 0.28, 0.22 and 0.17 (74.1%, 79.7% and 83.5% of relative reduction, respectively) after 12, 24 and 36 months of treatment, P |
| Databáze: | OpenAIRE |
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