Ebola Virus Neutralizing Antibodies Detectable in Survivors of theYambuku, Zaire Outbreak 40 Years after Infection

Autor: Rimoin, Anne W, Lu, Kai, Bramble, Matthew S, Steffen, Imke, Doshi, Reena H, Hoff, Nicole A, Mukadi, Patrick, Nicholson, Bradly P, Alfonso, Vivian H, Olinger, Gerrard, Sinai, Cyrus, Yamamoto, Lauren K, Ramirez, Christina M, Okitolonda Wemakoy, Emile, Kebela Illunga, Benoit, Pettitt, James, Logue, James, Bennett, Richard S, Jahrling, Peter, Heymann, David L, Piot, Peter, Muyembe-Tamfum, Jean Jacques, Hensley, Lisa E, Simmons, Graham
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Time Factors
viruses
Viral Plaque Assay
medicine.disease_cause
Antibodies
Viral
Medical and Health Sciences
Neutralization
Serology
Disease Outbreaks
Ebola virus
Surveys and Questionnaires
80 and over
Immunology and Allergy
2.1 Biological and endogenous factors
Viral
Survivors
Aetiology
Neutralizing
Antigens
Viral
Aged
80 and over
biology
virus diseases
Biological Sciences
Middle Aged
Ebolavirus
humanities
Infectious Diseases
Ebola
Viruses
virus neutralization
Democratic Republic of the Congo
serological response
Female
Antibody
Infection
filovirus
Adult
Adolescent
Enzyme-Linked Immunosorbent Assay
and over
Microbiology
Virus
Antibodies
Vaccine Related
03 medical and health sciences
Major Articles and Brief Reports
Young Adult
Plaque reduction neutralization test
VP40
Neutralization Tests
Biodefense
medicine
Humans
Antigens
Aged
business.industry
Prevention
Outbreak
biochemical phenomena
metabolism
and nutrition
Hemorrhagic Fever
Ebola
Virology
Antibodies
Neutralizing
030104 developmental biology
Emerging Infectious Diseases
Good Health and Well Being
biology.protein
Hemorrhagic Fever
Immunization
business
Zdroj: The Journal of Infectious Diseases
The Journal of infectious diseases, vol 217, iss 2
ISSN: 1537-6613
0022-1899
DOI: 10.1093/infdis/jix584
Popis: Duration of immunity against Ebola virus among survivors remains unclear. We assessed serological immune profiles and retention of Ebola virus neutralizing antibodies in 14 survivors of the 1976 Yambuku outbreak 40 years postinfection, providing the longest documentation of such measures reported.
The first reported outbreak of Ebola virus disease occurred in 1976 in Yambuku, Democratic Republic of Congo. Antibody responses in survivors 11 years after infection have been documented. However, this report is the first characterization of anti-Ebola virus antibody persistence and neutralization capacity 40 years after infection. Using ELISAs we measured survivor’s immunological response to Ebola virus Zaire (EBOV) glycoprotein and nucleoprotein, and assessed VP40 reactivity. Neutralization of EBOV was measured using a pseudovirus approach and plaque reduction neutralization test with live EBOV. Some survivors from the original EBOV outbreak still harbor antibodies against all 3 measures. Interestingly, a subset of these survivors’ serum antibodies could still neutralize live virus 40 years postinitial infection. These data provide the longest documentation of both anti-Ebola serological response and neutralization capacity within any survivor cohort, extending the known duration of response from 11 years postinfection to at least 40 years after symptomatic infection.
Databáze: OpenAIRE
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