Newcastle disease virus: Current status and our understanding
| Autor: | Sugandha Sinha, Sachin Kumar, Moushumee Das, Ketan A. Ganar |
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| Rok vydání: | 2014 |
| Předmět: |
Serotype
Cancer Research animal structures viruses Genetic Vectors Newcastle disease virus Disease Biology Newcastle disease Article Virus Birds Family Paramyxoviridae Paramyxovirus Virology Animals Humans Pathogenicity Whole genome sequencing Drug Carriers Attenuated vaccine Bird Diseases biology.organism_classification Oncolytic virus Biological Therapy Oncolytic Viruses Infectious Diseases Reverse genetics system |
| Zdroj: | Virus Research |
| ISSN: | 0168-1702 |
| Popis: | Highlights • Historical perspective and global scenario about Newcastle disease. • Characteristics about Newcastle disease virus genome. • Replication and pathogenicity of Newcastle disease virus. • Use of Newcastle disease virus as a vaccine vector. • Newcastle disease virus as an oncolytic agent. Newcastle disease (ND) is one of the highly pathogenic viral diseases of avian species. ND is economically significant because of the huge mortality and morbidity associated with it. The disease is endemic in many third world countries where agriculture serves as the primary source of national income. Newcastle disease virus (NDV) belongs to the family Paramyxoviridae and is well characterized member among the avian paramyxovirus serotypes. In recent years, NDV has lured the virologists not only because of its pathogenic potential, but also for its oncolytic activity and its use as a vaccine vector for both humans and animals. The NDV based recombinant vaccine offers a pertinent choice for the construction of live attenuated vaccine due to its modular nature of transcription, minimum recombination frequency, and lack of DNA phase during replication. Our current understanding about the NDV biology is expanding rapidly because of the availability of modern molecular biology tools and high-throughput complete genome sequencing. |
| Databáze: | OpenAIRE |
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