Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus)
Autor: | Ivona Pandrea, James D. Jentsch, Cassandra Benjamin, Nelson B. Freimer, Jen Chieh Lee, Tianyu He, Maurice Newton, Anna J. Jasinska, Giovanni Coppola |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
CD4-Positive T-Lymphocytes Neutrophils Down-Regulation lcsh:Medicine Biology medicine.disease_cause Stress Article Transcriptome 03 medical and health sciences 0302 clinical medicine Immune system Downregulation and upregulation Clinical Research Behavioral and Social Science Chlorocebus aethiops medicine Genetics 2.1 Biological and endogenous factors Animals Platelet activation Vervet monkey Longitudinal Studies Aetiology lcsh:Science Multidisciplinary Inflammatory and immune system Stressor lcsh:R Immune dysregulation biology.organism_classification Up-Regulation 030104 developmental biology Mental Health Good Health and Well Being Immunology Behavioural genetics Psychological Cytokines lcsh:Q Chemokines Psychosocial Stress and resilience 030217 neurology & neurosurgery Biomarkers Stress Psychological |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scientific Reports Scientific reports, vol 10, iss 1 |
ISSN: | 2045-2322 |
Popis: | Psychosocial stressors - life events that challenge social support and relationships - represent powerful risk factors for human disease; included amongst these events are relocation, isolation and displacement. To evaluate the impact of a controlled psychosocial stressor on physiology and underlying molecular pathways, we longitudinally studied the influence of a 28-day period of quarantine on biomarkers of immune signalling, microbial translocation, glycaemic health and blood transcriptome in the wild-born vervet monkey. This event caused a coordinated, mostly transient, reduction of circulating levels of nine immune signalling molecules. These were paralleled by a massive dysregulation of blood transcriptome, including genes implicated in chronic pathologies and immune functions. Immune and inflammatory functions were enriched among the genes downregulated in response to stress. An upregulation of genes involved in blood coagulation, platelet activation was characteristic of the rapid response to stress induction. Stress also decreased neutrophils and increased CD4 + T cell proportions in blood. This model of psychosocial stress, characterised by an immune dysregulation at the transcriptomic, molecular and cellular levels, creates opportunities to uncover the underlying mechanisms of stress-related diseases with an immune component, including cardiovascular diseases and susceptibility to infections. |
Databáze: | OpenAIRE |
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