Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus)

Autor: Ivona Pandrea, James D. Jentsch, Cassandra Benjamin, Nelson B. Freimer, Jen Chieh Lee, Tianyu He, Maurice Newton, Anna J. Jasinska, Giovanni Coppola
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
CD4-Positive T-Lymphocytes
Neutrophils
Down-Regulation
lcsh:Medicine
Biology
medicine.disease_cause
Stress
Article
Transcriptome
03 medical and health sciences
0302 clinical medicine
Immune system
Downregulation and upregulation
Clinical Research
Behavioral and Social Science
Chlorocebus aethiops
medicine
Genetics
2.1 Biological and endogenous factors
Animals
Platelet activation
Vervet monkey
Longitudinal Studies
Aetiology
lcsh:Science
Multidisciplinary
Inflammatory and immune system
Stressor
lcsh:R
Immune dysregulation
biology.organism_classification
Up-Regulation
030104 developmental biology
Mental Health
Good Health and Well Being
Immunology
Behavioural genetics
Psychological
Cytokines
lcsh:Q
Chemokines
Psychosocial
Stress and resilience
030217 neurology & neurosurgery
Biomarkers
Stress
Psychological
Zdroj: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific reports, vol 10, iss 1
ISSN: 2045-2322
Popis: Psychosocial stressors - life events that challenge social support and relationships - represent powerful risk factors for human disease; included amongst these events are relocation, isolation and displacement. To evaluate the impact of a controlled psychosocial stressor on physiology and underlying molecular pathways, we longitudinally studied the influence of a 28-day period of quarantine on biomarkers of immune signalling, microbial translocation, glycaemic health and blood transcriptome in the wild-born vervet monkey. This event caused a coordinated, mostly transient, reduction of circulating levels of nine immune signalling molecules. These were paralleled by a massive dysregulation of blood transcriptome, including genes implicated in chronic pathologies and immune functions. Immune and inflammatory functions were enriched among the genes downregulated in response to stress. An upregulation of genes involved in blood coagulation, platelet activation was characteristic of the rapid response to stress induction. Stress also decreased neutrophils and increased CD4 + T cell proportions in blood. This model of psychosocial stress, characterised by an immune dysregulation at the transcriptomic, molecular and cellular levels, creates opportunities to uncover the underlying mechanisms of stress-related diseases with an immune component, including cardiovascular diseases and susceptibility to infections.
Databáze: OpenAIRE
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