Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?
| Autor: | David Chadwick, N. Rajgopalan, M. D. M. Shaw, Patrick M. Foy, Anthony L. Johnson |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Phenytoin Adolescent Premedication medicine.medical_treatment Drug Administration Schedule law.invention Epilepsy Postoperative Complications Randomized controlled trial Actuarial Analysis law Humans Medicine Prospective Studies Craniotomy Aged Brain Diseases Dose-Response Relationship Drug business.industry Incidence (epidemiology) Electroencephalography Carbamazepine Middle Aged medicine.disease Psychiatry and Mental health Anticonvulsant Anesthesia Female Surgery Neurology (clinical) business Research Article Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 55:753-757 |
| ISSN: | 0022-3050 |
| Popis: | A total of 276 patients with a high risk of developing postoperative seizures were randomised to treatment with carbamazepine or phenytoin for six or 24 months, or to no treatment. No significant differences were found (though the confidence limits were fairly wide) between the regimes in respect of the incidence of seizures or death. In a substantial proportion of the patients postoperative epilepsy remained a continuing disability. A high incidence of drug-related side effects was found in the treatment groups. Prophylactic anticonvulsants cannot therefore be recommended routinely following supratentorial craniotomy. |
| Databáze: | OpenAIRE |
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