Prostaglandin E2: Midterm abortion in rats using Silastic-PVP tubes
| Autor: | Shiva K. Saksena, I.F. Lau, M. C. Chang |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Time Factors Vinyl Compounds Injections Subcutaneous Uterus Abortion Tritium Biochemistry Endocrinology Pregnancy In vivo Internal medicine Methods medicine Animals Labor Induced Prostaglandin E2 Acrylamides Fetus Estradiol business.industry Silastic Pyrrolidinones In vitro Rats Sodium salt medicine.anatomical_structure Delayed-Action Preparations Prostaglandins Female lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | Prostaglandins. 7:507-514 |
| ISSN: | 0090-6980 |
| DOI: | 10.1016/0090-6980(74)90095-1 |
| Popis: | The results of the present study establish that 1.5 mg PGE2 (lyophilized sodium salt) incorporated in one cm long open-ended Silastic-polyvinylpyrrolidone (PVP) tube when inserted into 10 day pregnant rats induced abortion within 70–72 hours in all the treated rats. A combined treatment of PGE2 and 17β-estradiol failed to increase the abortion inducing effect of a Silastic-PVP-PGE2 tube. It is observed that PGE2 is about 4 times less potent than PGF2α in inducing midterm abortion in rats. It is suggested that either PGE2 exerts luteolytic effect after being converted in vivo to PGF2α, although how it occurs is not clear; or PGE2 causes expulsion of the fetuses by its uterine stimulating property. 17β- estradiol increases the uterine synthesis of PGF2α as described earlier but seems not affecting the production of PGE2 by the uterus. The release rate of 3H-PGE2 from Silastic-PVP tube in vitro and in vivo is also described. |
| Databáze: | OpenAIRE |
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