Mechanical consequences of allergic induced remodeling on mice airway resistance and compressibility
| Autor: | Annette Robichaud, James G. Martin, Mauro Novali, Toby K. McGovern, Karim H. Shalaby, Thomas F. Schuessler, Andrea Benedetti, Liah Fereydoonzad |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Ovalbumin Physiology Airway hyperresponsiveness 030204 cardiovascular system & hematology Muscle Smooth Vascular Bronchoconstrictor Agents Allergen challenge Random Allocation 03 medical and health sciences 0302 clinical medicine Airway resistance Respiratory Hypersensitivity Tidal Volume medicine Animals Respiratory system Methacholine Chloride Mice Inbred BALB C biology business.industry Airway Resistance General Neuroscience respiratory system Elasticity respiratory tract diseases Disease Models Animal 030228 respiratory system Acute Disease Chronic Disease Immunology biology.protein Airway Remodeling Female Bronchoconstriction Methacholine Goblet Cells medicine.symptom Pulmonary Ventilation Airway business medicine.drug |
| Zdroj: | Respiratory Physiology & Neurobiology. 218:11-20 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2015.07.007 |
| Popis: | The effect of remodeling on airway function is uncertain. It may affect airway compressibility during forced expirations differently than airflow resistance, providing a tool for its assessment. The aim of the current study was to compare the effects of acute and chronic antigen challenge on methacholine-induced bronchoconstriction assessed from resistance and maximal tidal expiratory flow. Balb/C mice were sensitized with ovalbumin (OVA) and challenged either daily for three days with intra-nasal OVA or daily for 5 days and three times a week for 5 subsequent weeks. Acute and chronic allergen challenge induced airway hyperresponsiveness (AHR) to methacholine. However the relationship between maximal tidal expiratory flow and resistance during methacholine challenge was different between the two conditions, suggesting that the determinants of AHR are not identical following acute and chronic allergen exposure. We conclude that the contrast of changes in maximal tidal expiratory flow and respiratory resistance during methacholine-induced bronchoconstriction may allow the detection of the mechanical consequences of airway remodeling. |
| Databáze: | OpenAIRE |
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