Relation between brain lesion location and clinical outcome in patients with severe traumatic brain injury: a diffusion tensor imaging study using voxel-based approaches
| Autor: | Eléonore Tollard, Stéphane Lehéricy, Vincent Perlbarg, Louis Puybasset, Habib Benali, Damien Galanaud |
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| Přispěvatelé: | Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anesthésie-réanimation [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Service d'imagerie médicale [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de Neuroradiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Center for NeuroImaging Research - CENIR, Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'imagerie médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Peer, Hal |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Internal capsule Adolescent Traumatic brain injury Corpus callosum 030218 nuclear medicine & medical imaging 03 medical and health sciences Young Adult 0302 clinical medicine Intensive care Fractional anisotropy medicine Image Processing Computer-Assisted [INFO.INFO-IM]Computer Science [cs]/Medical Imaging Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Inferior longitudinal fasciculus Research Articles Aged Brain Mapping Radiological and Ultrasound Technology Recovery of Function Middle Aged medicine.disease Surgery Diffusion Tensor Imaging Neurology nervous system Brain Injuries Anisotropy Female Neurology (clinical) Radiology Anatomy Psychology 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Human Brain Mapping Human Brain Mapping, Wiley, 2009, 30 (12), pp.3924-33. ⟨10.1002/hbm.20817⟩ Human Brain Mapping, 2009, 30 (12), pp.3924-n/a. ⟨10.1002/hbm.20817⟩ Hum Brain Mapp Human Brain Mapping, Wiley, 2009, 30 (12), pp.3924-n/a. ⟨10.1002/hbm.20817⟩ |
| ISSN: | 1065-9471 1097-0193 |
| DOI: | 10.1002/hbm.20817⟩ |
| Popis: | The early prediction of consciousness recovery from traumatic brain injury (TBI) is crucial to make decisions about the appropriate use of prolonged intensive care. Diffusion tensor imaging (DTI) has been proposed as a biomarker of white matter injury that could be used in a classification purpose. Instead of region‐of‐interest‐based approach, we applied voxel‐based approaches (voxel‐based DTI and tract‐based spatial statistics) on 30 patients with TBI to identify, without any prior, the brain regions that were specifically damaged in unfavorable 1‐year outcome group compared to the favorable one. DTI were acquired at mean 23 days (5–53 days) and two DTI‐derived indices, fractional anisotropy (FA) and apparent diffusion coefficient (ADC), were tested. Our results showed that (1) ADC is not a relevant biomarker for early 1‐year outcome prognosis; (2) FA measured in inferior longitudinal fasciculus, in cerebral peduncle, in posterior limb of the internal capsule, and in posterior corpus callosum is specifically decreased in unfavorable outcome group compare to the favorable one; (3) a linear discriminant analysis using the FA measured in these four regions showed good classification performance (sensitivity = 86% and specificity = 86%). These findings confirm the relevance of the use of DTI as biomarkers for consciousness recovery after TBI and support the possible use of these biomarkers for early classification of patients. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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