Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report
| Autor: | Michael R. Hamblin, Anita Saltmarche, Margaret A. Naeser, Kai Fai Ho, Lew Lim |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Biomedical Engineering Precuneus Hippocampus chemical and pharmacologic phenomena Neuropsychological Tests Risk Assessment Severity of Illness Index Sampling Studies Angular gyrus 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Cortex (anatomy) Internal medicine photobiomodulation medicine Humans Dementia Radiology Nuclear Medicine and imaging Low-Level Light Therapy Psychiatry Prefrontal cortex Default mode network Aged Original Research Aged 80 and over LLLT business.industry intranasal fungi LED Alzheimer's disease Prognosis medicine.disease Treatment Outcome 030104 developmental biology medicine.anatomical_structure Posterior cingulate Female business human activities transcranial 030217 neurology & neurosurgery dementia |
| Zdroj: | Photomedicine and Laser Surgery |
| ISSN: | 1557-8550 |
| DOI: | 10.1089/pho.2016.4227 |
| Popis: | Objective: This study investigated whether patients with mild to moderately severe dementia or possible Alzheimer's disease (AD) with Mini-Mental State Exam (MMSE) Baseline scores of 10–24 would improve when treated with near-infrared photobiomodulation (PBM) therapy. Background: Animal studies have presented the potential of PBM for AD. Dysregulation of the brain's default mode network (DMN) has been associated with AD, presenting the DMN as an identifiable target for PBM. Materials and methods: The study used 810 nm, 10 Hz pulsed, light-emitting diode devices combining transcranial plus intranasal PBM to treat the cortical nodes of the DMN (bilateral mesial prefrontal cortex, precuneus/posterior cingulate cortex, angular gyrus, and hippocampus). Five patients with mild to moderately severe cognitive impairment were entered into 12 weeks of active treatment as well as a follow-up no-treatment, 4-week period. Patients were assessed with the MMSE and Alzheimer's Disease Assessment Scale (ADAS-cog) tests. The protocol involved weekly, in-clinic use of a transcranial-intranasal PBM device; and daily at-home use of an intranasal-only device. Results: There was significant improvement after 12 weeks of PBM (MMSE, p |
| Databáze: | OpenAIRE |
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