ECMO in COVID-19 patients: a systematic review and meta-analysis
| Autor: | Pietro Bertini, Matteo Nocci, Fabio Guarracino, Pasquale Nardelli, Marco Falcone, Giovanni Landoni, Gianluca Paternoster |
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| Přispěvatelé: | Bertini, P., Guarracino, F., Falcone, M., Nardelli, P., Landoni, G., Nocci, M., Paternoster, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19) MEDLINE Review Article Extracorporeal Membrane Oxygenation Influenza Human medicine Clinical endpoint Humans Hospital Mortality Pandemics intensive care business.industry Mortality rate COVID-19 mortality Confidence interval critical care Anesthesiology and Pain Medicine surgical procedures operative Supportive psychotherapy Meta-analysis Relative risk Emergency medicine ARDS ECMO Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiothoracic and Vascular Anesthesia |
| ISSN: | 1532-8422 1053-0770 |
| Popis: | Objective: To analyze the survival rates of patients with COVID-19 supported with extracorporeal membrane oxygenation (ECMO) and compare the survival rates of patients with COVID-19 supported with ECMO to patients with influenza supported with ECMO. Design: A systematic review and meta-analysis to assess the impact of ECMO as supportive therapy of COVID-19. Setting: The authors performed a search through the Cochrane, EMBASE, and MEDLINE/PubMed databases from inception to February 19, 2021, for studies reporting hospitalized patients with COVID-19 managed with ECMO. Participants: A total of 134 studies were selected, including 6 eligible for the comparative meta-analysis of COVID-19 versus influenza. Interventions: The authors pooled the risk ratio and random effects model. Measurements and Main Results: The primary endpoint was the overall mortality of patients with COVID-19 receiving ECMO. Of the total number of 58,472 patients with COVID-19 reported, ECMO was used in 4,044 patients. The analysis suggested an overall in-hospital mortality of 39% (95% CI 0.34-0.43). In the comparative analysis, patients with COVID-19 on ECMO had a higher risk ratio (RR) for mortality when compared to influenza patients on ECMO: 72/164 (44%) v 71/186 (38%) RR 1.34; 95% CI 1.05-1.71; p = 0.03. Conclusions: ECMO could be beneficial in patients with COVID-19, according to the authors’ meta-analysis. The reported mortality rate was 39%. This systematic analysis can provide clinical advice in the current era and ongoing pandemic. |
| Databáze: | OpenAIRE |
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