Effects of a Preload on Reduction of Food Intake by GLP-1 in Healthy Subjects
| Autor: | Markus Knupp, Lukas Degen, Jürgen Drewe, Franziska Zimmerli, Sibylle Oesch, Christoph Beglinger, Daniel Matzinger |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Food intake media_common.quotation_subject Satiety Response Eating Glucagon-Like Peptide 1 Internal medicine Humans Medicine media_common business.industry Stomach digestive oral and skin physiology Gastroenterology Healthy subjects Appetite Glucagon-like peptide-1 Preload Endocrinology medicine.anatomical_structure business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Digestion. 74:78-84 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000097585 |
| Popis: | Background/Aims: Glucagon-like peptide-1 (GLP-1) inhibits food intake in animals and humans. Whether GLP-1 interacts with other satiety signals to modulate food intake is unknown. We investigated therefore in healthy volunteers the potential interactions of GLP-1 with signals from the stomach in regulating food intake. Methods: Three sequential, double-blind, crossover studies were performed in male subjects: (1) 12 subjects underwent four experiments (preloads) 20 min before meal intake; (2) 12 volunteers received intravenous (i.v.) GLP-1 (0.9 pmol/kg/min) or saline; (3) subjects received i.v. GLP-1 or saline (control) together with a preload of either 400 ml water or 400 ml protein shake. The effect of these treatments on food intake and feelings of hunger was quantified. Subjects were free to eat and drink as much as they wished. Results: GLP-1 induced a reduction in food and calorie intake (p < 0.005) compared to controls. If combined with a protein preload, the inhibitory effect of GLP-1 on food intake was markedly increased (p < 0.001). Furthermore, a decrease in hunger feelings and an increase in satiety feelings was documented. Conclusion: GLP-1 interacts with signals from the stomach to modulate energy intake in humans. The signal is only initiated by nutrient-based distension, but not with gastric distension of the fundus alone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|