Focal nonconvulsive status epilepticus in children: clinical and electroencephalographic features in 38 patients
| Autor: | Duccio Maria Cordelli, Lucia Maltoni, Silvia Bonetti, Valentina Marchiani, Veronica Di Pisa |
|---|---|
| Přispěvatelé: | Maltoni L., Di Pisa V., Marchiani V., Bonetti S., Cordelli D.M. |
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Intensive Care Unit Status epilepticus Electroencephalography law.invention Eeg patterns 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Status Epilepticus law Retrospective Studie medicine Humans In patient 030212 general & internal medicine EEG Child Retrospective Studies Nonconvulsive status epilepticu medicine.diagnostic_test business.industry Inpatient setting medicine.disease Intensive care unit Intensive Care Units Neurology Etiology Neurology (clinical) Altered mental statu medicine.symptom business 030217 neurology & neurosurgery Human |
| Zdroj: | Epilepsybehavior : EB. 117 |
| ISSN: | 1525-5069 |
| Popis: | Purpose The aim of this study was to characterize clinically, etiologically, and electroencephalographically focal Nonconvulsive Status Epilepticus (NCSE) in children. Moreover, we tried to identify focal NCSE features distinguishing between different ages, NCSE etiologies, and cases of de novo onset. Methods We retrospectively identified patients (aged 1 month to 18 years) who had EEG-documented focal NCSE between January 2001 and December 2019. We analyzed the clinical features, etiology, and EEG features of each event. Results Thirty-eight patients were included in this study. NCSE had a de novo onset in 26 patients and was the first manifestation of previously undiagnosed epilepsy in 12 patients. NCSE etiology was acute symptomatic in 13 patients. Acute symptomatic NCSE events were mainly observed in hospitalized children, were usually longer, and had a significantly higher frequency of repetitive EEG patterns than other etiologies. In patients with epilepsy, the etiology of NCSE was remote symptomatic in 14, progressive in 6, and cryptogenic in 5; a definite or suspected genetic disorder was observed in 11. EEG localization was frequent in posterior regions (18 children). Eleven patients had refractory NCSE and 4 required admission to the intensive care unit. Conclusion Focal NCSE in children is more frequent in the first years of life, mainly involves posterior regions, and often has de novo onset. In the case of de novo focal NCSE both acute symptomatic NCSE and new-onset epilepsy must be considered and investigated. A higher frequency of repetitive EEG patterns and an inpatient setting are significantly associated with acute symptomatic NCSE. |
| Databáze: | OpenAIRE |
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