Expression of membrane receptor for tumour necrosis factor on human blood lymphocytes
| Autor: | L Flego, Heddy Zola, H Weedon |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
CD4-Positive T-Lymphocytes
0301 basic medicine Pathology medicine.medical_specialty Necrosis medicine.medical_treatment Receptor expression Lymphocyte Palatine Tonsil Immunology Biology Lymphocyte Activation Receptors Tumor Necrosis Factor Immunophenotyping 03 medical and health sciences 0302 clinical medicine Cell surface receptor medicine Humans Immunology and Allergy Lymphocytes Receptor Cells Cultured B-Lymphocytes Tumor Necrosis Factor-alpha Mantle zone Cell Membrane Antibodies Monoclonal hemic and immune systems Cell Biology Flow Cytometry Molecular biology biological factors 030104 developmental biology Cytokine medicine.anatomical_structure Tumor necrosis factor alpha biological phenomena cell phenomena and immunity medicine.symptom 030215 immunology |
| Zdroj: | Immunology and Cell Biology. 71:281-288 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1993.33 |
| Popis: | Using a monoclonal antibody against the human p75 tumour necrosis factor receptor (TNFR-I) combined with a high-sensitivity immunofluorescence flow cytometric procedure, a proportion of peripheral blood lymphocytes can be shown to express TNFR-I constitutively. Approximately 50% of peripheral blood lymphocytes consisting mostly of CD4 cells and including most CD45R0-positive cells, express TNFR-I. Receptor expression is increased by a variety of activation signals. Only a minority (up to 30%) of tonsil B cells express measurable levels of TNFR-I. The tonsil B cells which express TNFR-I include both cells with a germinal centre cell phenotype and cells with the phenotype of the follicular mantle zone. Activation of B cells with anti-immunoglobulin, alone or in combination with interleukin-4 or interleukin-2, increases receptor expression, particularly in cells with the phenotype of mantle zone cells. The functional significance of constitutive expression of TNFR by blood and tissue lymphocytes is discussed. |
| Databáze: | OpenAIRE |
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