Extra-cellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility
| Autor: | Monika E. Dolega, Giovanni Cappello, Sylvain Monnier, Pierre Recho, Benjamin Brunel, Jean-François Joanny |
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| Přispěvatelé: | Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Biophysique (BIOPHYSIQUE), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Chaire Matière molle et biophysique, Collège de France (CdF (institution)) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
tumor multicellular aggregates QH301-705.5 extracellular matrix Science [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph] Morphogenesis Motility 01 natural sciences General Biochemistry Genetics and Molecular Biology Cell Line Extracellular matrix 03 medical and health sciences Mice Cell Movement 0103 physical sciences physics of living systems Animals cancer composite Biology (General) 010306 general physics Tissue homeostasis mouse Cell Proliferation General Immunology and Microbiology Cell growth Chemistry General Neuroscience mechanical stress General Medicine Internal cell Pressure sensor compression poro-active Biomechanical Phenomena Multicellular organism 030104 developmental biology Biophysics Tumor Biology Medicine Insight |
| Zdroj: | eLife eLife, eLife Sciences Publication, 2021, 10, ⟨10.7554/eLife.63258⟩ eLife, Vol 10 (2021) |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.63258⟩ |
| Popis: | International audience; Imposed deformations play an important role in morphogenesis and tissue homeostasis, both in normal and pathological conditions. To perceive mechanical perturbations of different types and magnitudes, tissues need appropriate detectors, with a compliance that matches the perturbation amplitude. By comparing results of selective osmotic compressions of CT26 mouse cells within multicellular aggregates and global aggregate compressions, we show that global compressions have a strong impact on the aggregates growth and internal cell motility, while selective compressions of same magnitude have almost no effect. Both compressions alter the volume of individual cells in the same way over a shor-timescale, but, by draining the water out of the extracellular matrix, the global one imposes a residual compressive mechanical stress on the cells over a long-timescale, while the selective one does not. We conclude that the extracellular matrix is as a sensor that mechanically regulates cell proliferation and migration in a 3D environment. |
| Databáze: | OpenAIRE |
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