Aging decreases retinoic acid and triiodothyronine nuclear expression in rat liver: exogenous retinol and retinoic acid differentially modulate this decreased expression

Autor: Véronique Pallet, Catherine Noël-Suberville, P Grolier, V Enderlin, V Azaı̈s-Braesco, Henri Garcin, Paul Higueret
Přispěvatelé: Unité sous contrat nutrition et signalisation cellulaire, Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université
Rok vydání: 1998
Předmět:
MESH: Cell Nucleus
Male
medicine.medical_specialty
Aging
Retinyl Esters
MESH: Diterpenes
MESH: Rats
Tissue transglutaminase
Receptors
Retinoic Acid
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Retinoic acid
Malic enzyme
Tretinoin
Biology
chemistry.chemical_compound
Internal medicine
Retinyl palmitate
medicine
Animals
MESH: Aging
MESH: Animals
MESH: Receptors
Thyroid Hormone
Rats
Wistar
Receptor
Vitamin A
MESH: Vitamin A
MESH: Receptors
Retinoic Acid
Cell Nucleus
MESH: Tretinoin
Triiodothyronine
Receptors
Thyroid Hormone
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
Retinol
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
MESH: Rats
Wistar
MESH: Male
Rats
Endocrinology
chemistry
Nuclear receptor
Liver
biology.protein
Diterpenes
MESH: Liver
Developmental Biology
Zdroj: Mechanisms of Ageing and Development
Mechanisms of Ageing and Development, 1997, 99 (2), pp.123-136. ⟨10.1016/s0047-6374(97)00098-5⟩
ISSN: 0047-6374
DOI: 10.1016/s0047-6374(97)00098-5⟩
Popis: International audience; The expression of nuclear receptors of retinoic acid (RAR) and triiodothyronine (TR) was analyzed in the liver of rats aged 2.5 (young), 6 (adult) and 24 (aged) months. In aged rats, decreased binding properties, binding capacity (Cmax) and affinity (Ka), of nuclear receptors were observed. This resulted, at least in part, from decreased transcription of receptor genes in that the amount of their mRNA also decreased. Moreover, the activity of malic enzyme (ME) and tissue transglutaminase (tTG), whose genes are TR and RAR responsive, respectively, was reduced in aged rats. These results are in agreement with the decreased binding capacity of these receptors. An inducer-related increase of RAR and TR expression was observed 24 h after a single dose of retinoic acid administration (5 mg/kg), while retinol administration (retinyl palmitate, 13 mg/kg) was without incidence on nuclear receptor expression in aged rats.
Databáze: OpenAIRE
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