Pro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer
| Autor: | George Ilonidis, Theodoros Bischiniotis, Nikolaos Barbetakis, Sofia Papoti, Maria Christopoulou, Athanasios N. Saratzis, Eudokia Mandala, Dimitrios Platogiannis, Christos Lafaras |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Lung Neoplasms medicine.drug_class Pro-Brain Natriuretic Peptide Diagnostic tools Bioinformatics Sensitivity and Specificity Heart Neoplasms Text mining Internal medicine Carcinoma Non-Small-Cell Lung Natriuretic Peptide Brain medicine Natriuretic peptide Biomarkers Tumor Humans In patient cardiovascular diseases Cardiac disorders Lung cancer Aged Aged 80 and over business.industry Reproducibility of Results Hematology General Medicine Middle Aged medicine.disease Peptide Fragments Oncology cardiovascular system Cardiology Female Non small cell business human activities hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Onkologie. 32(7) |
| ISSN: | 1423-0240 |
| Popis: | B-type natriuretic peptide (BNP) and N-terminal-pro-BNP (NT-pro-BNP) are important diagnostic tools for patients with suspected cardiac disorders. The aim of this study was to evaluate the predictive value of plasma NT-pro-BNP in identifying cardiac metastases in patients with non-small cell lung cancer (NSCLC) and dyspnoea.A total of 120 patients, median age 62 years (range 46-83), with NSCLC and dyspnoea were studied. Patients with heart failure or documented coronary artery disease were excluded. Echocardiographic imaging was used to detect cardiac metastases and estimate global left ventricular function. Ejection fraction and E/A ratio from transmitral inflow pattern were calculated. Plasma NT-pro-BNP was also measured. 72 patients (72/120, 60%) with cardiac metastases were identified.NT-pro-BNP was significantly higher in patients with metastases (1347.5 +/- 1004.30 pg/ml vs. 159.02 +/- 93.29 pg/ml; p = 0.001). No differences between groups, regarding s-creatinine (p = 0.45), haemoglobin (p = 0.71), left ventricular hypertrophy (p = 0.91), and diastolic dysfunction (p = 0.79), were observed.Plasma NT-pro-BNP is remarkably elevated in patients with NSCLC and myocardial/pericardial infiltrations and may be used as a sensitive marker for detecting cardiac metastases in these patients. |
| Databáze: | OpenAIRE |
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